Histone deacetylase 6 inhibitor ACY1215 offers a protective effect through the autophagy pathway in acute liver failure

Chen Qian; Wang Yao; Jiao Fang-Zhou; Shi Chun-Xia; Gong Zuo-Jiong

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Histone deacetylase 6 inhibitor ACY1215 offers a protective effect through the autophagy pathway in acute liver failure

机译：组蛋白脱乙酰酶6抑制剂ACY1215通过急性肝功能衰竭的自噬途径提供保护效果

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摘要

Aim: The purpose of the present study was to elucidate the protective effect of histone deacetylase 6 inhibitor ACY1215 on autophagy pathway in acute liver failure (ALF).

机译：目的：本研究的目的是阐明组蛋白脱乙酰酶6抑制剂ACY1215对急性肝功能衰竭（ALF）的自噬途径的保护作用。

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来源
《Life sciences》 |2019年第1期|共8页
作者
Chen Qian; Wang Yao; Jiao Fang-Zhou; Shi Chun-Xia; Gong Zuo-Jiong;
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作者单位

Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Hubei Peoples R China;

Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Hubei Peoples R China;

Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Hubei Peoples R China;

Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Hubei Peoples R China;

Wuhan Univ Dept Infect Dis Renmin Hosp Wuhan 430060 Hubei Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Acute liver failure; Histone deacetylase 6 inhibitor; ACY1215; Autophagy;

机译：急性肝功能衰竭;组蛋白脱乙酰酶6抑制剂;ACY1215;自噬;

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专利

1. Histone deacetylase 6 inhibitor ACY1215 offers a protective effect through the autophagy pathway in acute liver failure [J] . Chen Qian, Wang Yao, Jiao Fang-Zhou, Life sciences . 2019,第1期

机译：组蛋白脱乙酰酶6抑制剂ACY1215通过急性肝功能衰竭的自噬途径提供保护效果
2. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway [J] . Qian Chen, Yao Wang, Fangzhou Jiao, Journal of cellular and molecular medicine. . 2021,第15期

机译：HDAC6抑制剂ACY1215通过调节ATM / F-Actin信号通路来抑制急性肝功能衰竭中NLRP3炎性的活化
3. Histone deacetylase 6 inhibitor ACY-1215 protects against experimental acute liver failure by regulating the TLR4-MAPK/NF-kappa B pathway [J] . Zhang Wen-bin, Zhang Hai-yue, Jiao Fang-zhou, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：组蛋白脱乙酰酶6抑制剂ACY-1215通过调节TLR4-MAPK / NF-Kappa B途径来保护实验急性肝功能衰竭
4. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence [C] . Xinliang Mao, Depei Wu, Suzanne Trudel, International conference of molecular simulations and applied informatics technologies . 2012

机译：三环抗抑郁药阿米替林通过抑制组蛋白脱乙酰基酶抑制D-cyclin反式激活并诱导骨髓瘤细胞凋亡：体外和计算机证据。
5. Anti-ovarian cancer effects of histone deacetylase inhibitors and calpain inhibitor. [D] . Lapinska, Karolina Eva. 2016

机译：组蛋白脱乙酰基酶抑制剂和钙蛋白酶抑制剂的抗卵巢癌作用。
6. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway [O] . Qian Chen, Yao Wang, Fangzhou Jiao, 2021

机译：HDAC6抑制剂ACY1215通过调节ATM / F-Actin信号通路来抑制急性肝功能衰竭中NLRP3炎性的活化
7. Modulations of Histone Deacetylase 2 Offer a Protective Effect through the Mitochondrial Apoptosis Pathway in Acute Liver Failure [O] . Yao Wang, Fan Yang, Fang-Zhou Jiao, 2019

机译：组蛋白脱乙酰酶2的调节通过急性肝衰竭中的线粒体凋亡途径提供了保护作用

Histone deacetylase 6 inhibitor ACY1215 offers a protective effect through the autophagy pathway in acute liver failure

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