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首页> 外文期刊>Life sciences >Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction
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Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction

机译：罗斯莱在饮食诱导的肥胖大鼠模型中进行心肌梗死的心脏保护剂

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Abstract Aims Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Main methods Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s.c, 2days) and divided into three groups: (1) OB+MI, (2) OB+MI+R and (3) OB+MI+enalapril for another 4weeks. Key findings Roselle ameliorated OB and OB+MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB+MI groups were all attenuated by roselle. Significance These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB+MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.
机译：摘要目标肥胖增加了氧化应激介导的高血压和心肌梗死（MI）的风险。本研究旨在调查罗萨勒含水提取物（R）对肥胖（OB）大鼠的心脏毒性的作用，以及对MI进行的ob大鼠。主要方法雄性Sprague-Dawley大鼠用正常的饮食或高脂饮食供给8周。首先，将OB大鼠分为（1）OB和（2）OB + R（100mg / kg，p.o，28days）。然后，OB大鼠进行MI（ISO，85mg / kg，SC，2天）并分为三组：（1）OB + Mi，（2）OB + Mi + R和（3）OB + Mi + enalapril另一个4周。主要发现Roselle改善了OB和OB + MI的心脏收缩功能障碍和减少的心脏肥大和纤维化。 ob和ob + mi组中增加的氧化标记和降低的抗氧化酶全部由roselle衰减。意义这些观察结果表明ROSELLE对OB和OB + MI大鼠心脏功能障碍的保护作用，这表明其潜力将成为未来肥胖和肥胖患者的营养素产品。

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