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首页> 外文期刊>Life sciences >Mechanisms of action for α 1 -adrenoceptor blockers in storage symptoms with new insights into the micturition reflex
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Mechanisms of action for α 1 -adrenoceptor blockers in storage symptoms with new insights into the micturition reflex

机译：α1-adrenopector阻滞剂在储存症状中的作用机制，具有新的洞察于监测反射

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Abstract Elderly patients suffering from lower urinary tract symptoms with benign prostatic hyperplasia (BPH) are widely prescribed α 1 -adrenoceptor blockers (α 1 -blockers) to improve voiding and storage symptoms. The mechanism of action for improvements in voiding symptoms is well understood; tonus of the urethra and prostate are decreased and urinary flow rate is increased by α 1 -blockers. However, the mechanisms underlying storage symptoms have remained unclear, although detrusor hyperactivity has been identified as a significant factor. Previous investigations have yielded informative results, such as amelioration of reduced blood flow and afferent C-fiber activation, and the importance of the urothelium. Recently, the fascinating role of α 1A - and α 1D -adrenoceptor subtypes have been investigated for bladder function. Furthermore, the scope of this pathology covers both the bladder and that part of the central nervous system related to the micturition reflex. This review describes the beneficial effects of α 1 -blockers on storage symptoms and the pathogenesis of storage symptoms related to BPH, discusses the mechanisms of action for α 1 -blockers with reference to results from cystometry to suggest improvements in management that suppress detrusor hyperactivity, and examines the potential influence of α 1A - and α 1D -adrenoceptor subtypes on bladder activity. Graphical abstract Display Omitted Highlights ? α 1 -blockers suppress micturition reflex. ? α 1 -blockers modulate symptoms thorough α 1A - and α 1D -adrenoceptor subtypes in the brain, spinal cord and/or urinary bladder. ? The α 1D -adrenoceptor subtype may be more significant than the α 1A subtype for inhibiting of the micturition reflex.
机译：摘要患有患有良性前列腺增生（BPH）的患有下尿路症状（BPH）的年长患者是广泛规定的α1 - reneceptor阻滞剂（α1-伯桶），以改善排尿和储存症状。排尿症状改善的作用机制很好地理解;尿道和前列腺的舌头减少，α1-Blockers增加了尿流率。然而，储存症状的机制仍不清楚，尽管逼尿管多动症已被识别为重要因素。以前的调查产生了信息性结果，例如降低血液流动和传入的C-纤维激活的改善，以及尿路鞘的重要性。最近，已经研究了α1A和α1D-Drenceptor亚型的迷人作用用于膀胱功能。此外，该病理学的范围涵盖了与喷射反射有关的中枢神经系统的膀胱和该部分。本综述描述了α1-伯苯酯对储存症状的有益效果以及与BPH相关的储存症状的发病机制，讨论了α1 - 伯桶的作用机制，参考囊谱仪的结果表明抑制了抑制了逼尿肌多动症的管理改进，并检查α1A和α1D-adrenceptor亚型对膀胱活性的潜在影响。图形抽象显示省略了亮点？ α1-块抑制射流反射。还是α1-伯苯块调节症状彻底α1a - 和α1d-sadenceptor亚型在脑，脊髓和/或膀胱中。还是α1d-adrenoceptor亚型比α1a亚型更显着，用于抑制喷射反射。

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