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Cost-effective fabrication of photopolymer molds with multi-level microstructures for PDMS microfluidic device manufacture

机译:具有用于PDMS微流体装置制造的多级微结构的光聚合物模具的成本效益

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摘要

This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture. Multi-level microstructures can be performed by varying UVA exposure time and channel width. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and profilometry techniques have been employed to characterize the molds. Multiple molds with multi-level microstructures can be formed in a unique piece. Overall height/depth of the structures reaches up to 677 mu m and a minimum of 21 mu m. The method provides several advantages such as reduction of fabrication time, multiple structures with diverse topologies, a great variety of depth and height in a single mold and low cost of fabrication. The effectiveness of multi-level microstructure fabrication was evaluated by constructing PDMS microfluidic devices for cell culture and proliferation.
机译:本文介绍了具有多级微结构的光聚合物模具制造的方法,用于聚二甲基硅氧烷(PDMS)微流体装置制造。 可以通过不同的UVA曝光时间和沟道宽度来执行多级微结构。 扫描电子显微镜(SEM),原子力显微镜(AFM)和轮廓测量技术已经用于表征模具。 具有多级微结构的多个模具可以形成为独特的件。 结构的整体高度/深度达到677亩,最少21亩。 该方法提供了多种优点,例如减少制造时间,多种结构具有不同拓扑结构,单一模具的各种深度和高度,以及低制造成本。 通过构建用于细胞培养和增殖的PDMS微流体装置来评价多层次微观结构制造的有效性。

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  • 来源
    《RSC Advances》 |2020年第7期|共9页
  • 作者单位

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    Univ Fuerzas Armadas Ctr Nanociencia &

    Nanotecnol ESPE POB 171-5-231B Sangolqui Ecuador;

    Univ Freiburg Fac Med Med Ctr Dept Med 1 Freiburg Germany;

    Univ Freiburg Fac Med Med Ctr Dept Med 1 Freiburg Germany;

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    Univ Fuerzas Armadas Ctr Nanociencia &

    Nanotecnol ESPE POB 171-5-231B Sangolqui Ecuador;

    Univ Fuerzas Armadas Ctr Nanociencia &

    Nanotecnol ESPE POB 171-5-231B Sangolqui Ecuador;

    Univ Fuerzas Armadas Ctr Nanociencia &

    Nanotecnol ESPE POB 171-5-231B Sangolqui Ecuador;

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    UTN Fac Reg Haedo RA-1706 Buenos Aires DF Argentina;

    Univ Freiburg Fac Med Med Ctr Dept Med 1 Freiburg Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

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