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首页> 外文期刊>RSC Advances >Efficient acylation of gastrodin by Aspergillus oryzae whole-cells in non-aqueous media
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Efficient acylation of gastrodin by Aspergillus oryzae whole-cells in non-aqueous media

机译：在非水介质中的Aspergillus oryzae全细胞高效actrodin的actrodin

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摘要

Gastrodin, a bioactive compound extracted from the plant source of Gastrodia elata Blume, has a wide range of therapeutic effects on central nervous system (CNS) diseases, but suffers from poor brain permeability and short half-life in plasma. In this study, fatty acid esters of gastrodin were successfully synthesized by a whole cell-based biocatalytic method. Aspergillus oryzae cells showed different catalytic activities in the organic solvent systems tested. Tetrahydrofuran was confirmed as the most suitable pure organic solvent, with the highest substrate conversion of 98.0%. Addition of ionic liquids (ILs) into pyridine dramatically accelerated the reaction with conversion increased from 5.9% to 84.2%, and also changed the selectivity of the cells, mainly due to the use of IL-containing systems altering cell permeability and contact of the enzymes with solvent molecules possessing different polarities. The ester products were characterized by 13C-NMR and ESI-MS as gastrodin monoester and diester.
机译：Gastrodin，一种从植物胃腹部植物来源中提取的生物活性化合物，对中枢神经系统（CNS）疾病具有广泛的治疗作用，但患有较差的脑渗透性和血浆中的短生活。在该研究中，通过基于细胞的生物催化方法成功地合成了胃生成的脂肪酸酯。曲霉菌Oryzae细胞在测试的有机溶剂体系中显示出不同的催化活性。将四氢呋喃确认为最合适的纯有机溶剂，最高的基材转化率为98.0％。将离子液体（ILS）加入吡啶中显着加速转化的反应从5.9％增加到84.2％，并且还改变了细胞的选择性，主要是由于使用含Il的系统改变细胞渗透性和酶接触的渗透性和接触。溶剂分子具有不同的极性。酯产品的特征在于13C-NMR和ESI-MS作为腓酯单酯和二酯。

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  • 来源
    《RSC Advances》 |2019年第29期|共12页
  • 作者

    Li Xiaofeng; Ma Maohua; Xin Xuan; Tang Yuqian; Zhao Guanglei; Xiao Xinglong;

  • 作者单位

    South China Univ Technol Sch Food Sci &

    Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol State Key Lab Pulp &

    Paper Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn Wushan Rd 381 Guangzhou 510641 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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