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首页> 外文期刊>RSC Advances >Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester
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Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester

机译：丁香酚的磁化以制造磁性响应乳液的靶向递送的咖啡酸苯乙烷酯

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摘要

Fabrication of manipulative colloidal vehicles with appreciable stability under an eco-friendly, cross-linkage free environment has long been one of the major challenges in targeted delivery for curative, acoustic, and imaging purposes. A new targeted delivery system was developed in this paper based on magnetization of eugenol with magnetic Fe3O4 nanoparticles by simply evaporating water from the 3-phase system prior to a one-step coating of the oil using rice proteins to form core/shell structured composites. The droplets, examined as well-defined spheres with a mean hydrodynamic diameter of 204 nm, were metastable against long-term storage for up to 4 months, thermal treatment for up to 90 degrees C and UV (365 nm) radiation for up to 24 h. Furthermore, upon an external manipulation, the magnetic emulsions enhanced the anti-proliferation effects of encapsulated CAPE, an anti-cancer drug, on HCT-116 cells by over 20% compared to CAPE encapsulated in normal emulsions at dosages of 0.2 and 2 mg mL(-1). In principle, a wide variety of o/w emulsions can be magnetized using this approach. As a first step towards magnetic delivery, magnetization of oil may become a new targeted delivery strategy in the development of future site-specific diagnosis and treatment.
机译：在环保，交叉联动环境下具有明显稳定性的操纵胶体车辆的制造长期以来，长期以来一直是有针对性的疗效，声学和成像目的的主要挑战之一。本文在本文中基于用磁性Fe3O4纳米颗粒的磁化，通过在使用水稻蛋白的一步涂层之前，基于用磁Fe3O4纳米颗粒的磁化为磁性Fe3O4纳米颗粒的磁化，从而形成核心/壳结构复合材料。作为平均流体动力直径为204nm的平均流体动力直径的液滴是长期储存，长达4个月的长期储存，热处理高达90℃和UV（365nm）辐射，最多24个H。此外，在外部操纵时，与包封在0.2和2mg mL的正常乳液中的己岛相比，磁性乳液增强了包封的己内，抗癌药物，抗癌药物对HCT-116细胞的抗增殖效应。 （-1）。原则上，可以使用这种方法磁化各种各样的O / W乳液。作为磁力递送的第一步，石油的磁化可能成为未来现场诊断和治疗的开发中的新目标交付策略。

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  • 来源
    《RSC Advances》 |2017年第69期|共9页
  • 作者

    Wang Tao; Wang Ren; Chen Zhengxing; Zhong Qixin;

  • 作者单位

    Jiangnan Univ State Key Lab Food Sci &

    Technol Wuxi 214122 Peoples R China;

    Jiangnan Univ State Key Lab Food Sci &

    Technol Wuxi 214122 Peoples R China;

    Jiangnan Univ State Key Lab Food Sci &

    Technol Wuxi 214122 Peoples R China;

    Univ Tennessee Dept Food Sci &

    Technol Knoxville TN 37996 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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