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首页> 外文期刊>Surgical Endoscopy >Long-term follow-up after sleeve gastrectomy versus Roux-en-Y gastric bypass versus one-anastomosis gastric bypass: a prospective randomized comparative study of weight loss and remission of comorbidities
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Long-term follow-up after sleeve gastrectomy versus Roux-en-Y gastric bypass versus one-anastomosis gastric bypass: a prospective randomized comparative study of weight loss and remission of comorbidities

机译：套筒胃切除术后的长期随访者与Roux-Zh-Y胃旁路与单吻伤胃旁路（一种胃窦旁路）：一项潜在的随机对比研究体重减轻和缓解合并症

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BackgroundOne-Anastomosis Gastric Bypass (OAGB) has exponentially increased in the last decade, as it is associated with very low complications, mortality, readmissions and reoperations rates, and shows excellent short- and long-term benefits of weight loss and resolution of comorbidities. The aim of this study was to compare the effect of SG, RYGB, and OAGB, on short- and long-term weight loss and comorbidities resolution.MethodsA prospective randomized clinical study of all morbidly obese patients undergoing SG, RYGB, and OAGB, as primary bariatric procedures, was performed. Patients were randomly assigned into 3 groups: those patients undergoing SG, those ones undergoing RYGB and those ones undergoing OAGB. BMI, excess BMI loss (EBMIL) and remission of type 2 diabetes (T2DM), hypertension (HT), and dyslipidemia (DL) were assessed.Results600 patients were included in the study, 200 in each group. Follow-up rate at 5years postoperatively was 91% in SG group, 92% in RYGB, and 90% in OAGB. OAGB achieves significantly greater EBMIL than RYGB and SG at 1, 2, and 5years (p0.001, respectively). At 5 years, OAGB achieves significantly greater remission of T2DM (p=0.027), HT (p=0.006), and DL (p0.001) than RYGB and SG. RYGB did not show significant superiority than SG in short- and long-term remission of T2DM and HT, but achieves greater remission of DL (p0.001).ConclusionOAGB achieves superior mid- and long-term weight loss than RYGB and SG. There are no significant differences in weight loss between SG and RYGB at 1, 2, and 5years. OAGB achieves better short- and long-term resolution rates of DM, HT, and DL than SG and RYGB. RYGB and SG obtain similar T2DM and HT remissions, but RYGB reaches significantly greater rates of DL remission. ClinicalTrials.gov Identifier: NCT03467646.
机译：背景 - 吻合术秃发（OAGB）在过去十年中呈指数级增长，因为它与非常低的并发症，死亡率，入伍和重新进展率有关，并且表现出优异的减肥和分辨率的良好短期和长期益处。本研究的目的是比较SG，RYGB和OAGB对短期和长期减肥和合并分辨率的影响。在接受SG，RYGB和OAGB的所有病态肥胖患者的前瞻性随机临床研究。原发性肥胖症程序进行。患者被随机分配到3组：那些接受SG的患者，那些接受RYGB的那些接受OAGB的患者。评估BMI，过量的BMI丧失（EBMIL）和2型糖尿病（T2DM），高血压（HT）和血液化血症（DL）的缓解。患者均包含在研究中，每组200例。术后5年的随访率为Sg组的91％，Rygb的92％，oagb中90％。 OAGB在1,2和5年的RYGB和SG获得明显更大的EBMIL（分别分别为5°（P <0.001）。在5年后，OAGB达到比RYGB和SG的T2DM（P = 0.027），HT（P = 0.006）和DL（P <0.001）显着更大。 RYGB在T2DM和HT的短期和长期缓解中没有显着优于SG，但是达到了更高的DL（P <0.001）的缓解.ConclusionoAGB比RyGB和SG实现优异的中间和长期减肥。在1,2和5年的SG和RYGB之间的体重减轻差异没有显着差异。 OAGB实现了DM，HT和DL的更好的短期和长期分辨率，而不是SG和RYGB。 RYGB和SG获得了类似的T2DM和HT剩余，但RYGB达到了更大的DL缓解率。 ClinicalTrials.gov标识符：NCT03467646。

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