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Perspectives on Animal Models Utilized for the Research and Development of Regenerative Therapies for Articular Cartilage

机译：用于关节软骨再生疗法研究和开发的动物模型的观点

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摘要

Animal models are integral and indispensable for biomedical research and regenerative medicine studies, as these provide invaluable information for systemically evaluating the potential risks and efficacy of newly developed biomaterials, drugs, medical devices, and therapeutic modalities, prior to initiation of human clinical trials. Nevertheless, it is important to be aware of the unique strengths and limitations of the various different small and large animal models commonly utilized for biomedicalresearch as well as the various challenges faced in extrapolating results acquired from animal studies and the risks of data misinterpretation. This review will thus critically examine various animal models utilized for studies on articular cartilage regeneration. Particular emphasis will be placed on comparing and analyzing the unique strengths and limitations of each animal model, with the aim of establishing principles for evaluating the suitability of different animal models for individual studiesas well as for comprehensive interpretation and extrapolation of results obtained from various animal species. Additionally, this review will also discuss to evaluate animal studies with in situ imaging techniques, how the animal genome may result in variability in experimental outcomes, as well as the contribution of animal models to the development of cartilage tissue engineering.
机译：动物模型是生物医学研究和再生医学研究不可或缺的组成部分，因为它们为在人类临床试验开始之前系统评估新开发的生物材料，药物，医疗设备和治疗方式的潜在风险和功效提供了宝贵的信息。尽管如此，重要的是要意识到生物医学研究中通常使用的各种大小动物模型的独特优势和局限性，以及从动物研究获得的结果进行推断时面临的各种挑战以及数据误解的风险。因此，本综述将严格审查用于关节软骨再生研究的各种动物模型。将特别强调比较和分析每种动物模型的独特优势和局限性，目的是建立评估不同动物模型对个别研究的适用性以及对从各种动​​物物种获得的结果进行综合解释和外推的原则。此外，本篇综述还将讨论使用原位成像技术评估动物研究，动物基因组如何导致实验结果可变性以及动物模型对软骨组织工程发展的贡献。

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