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Cancer pain: An update of pharmacological approaches in pain therapy

机译：癌症疼痛：疼痛疗法中药理学方法的更新

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Purpose of review: This review discusses clinically oriented data on advances in pharmacological research of cancer pain therapy carried out during the last year. The aim is to ascertain whether well known guidelines for cancer pain prove to be adequate or require modification. Recent findings: There are alternatives to morphine, which is the standard drug, including oxycodone or methadone, with the problem of equivalence doses in the case of opioid rotation. Depending on the underlying pathophysiological mechanisms, adjuvant drugs are recommended, such as antidepressants and anticonvulsants for neuropathic pain, or bisphosphonates for metastasis bone pain. Current and future research will offer receptor-specific acting new drugs or old drugs under new indications. Summary: The recommendations of the World Health Organization ladder remain the mainstay of cancer pain management. These recommendations, however, are based more on expert opinions than on evidence-based data.
机译：综述的目的：这篇综述讨论了在去年进行的癌症止痛药理学研究进展的临床导向数据。目的是确定众所周知的针对癌症疼痛的指南是否足够或需要修改。最新发现：吗啡是标准药物吗啡的替代品，包括羟考酮或美沙酮，在阿片类药物旋转的情况下存在等效剂量的问题。根据潜在的病理生理机制，推荐使用辅助药物，例如用于神经性疼痛的抗抑郁药和抗惊厥药，或用于转移性骨痛的双膦酸盐。当前和未来的研究将在新的适应症下提供受体特异性作用的新药或旧药。简介：世界卫生组织阶梯的建议仍然是癌症疼痛管理的中流tay柱。但是，这些建议更多地基于专家意见，而不是基于证据的数据。

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