• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current drug targets. Infectious disorders >Macrolide resistance from the ribosome perspective.
【24h】

Macrolide resistance from the ribosome perspective.

机译：从核糖体角度看大环内酯耐药。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Macrolides are important antibiotics used in treatment of respiratory tract infections in humans. Although some of these compounds have been in use for 50 years, it has not been until the last few years that their mechanism of action and the nature of ribosomal-based resistance could be more fully understood. With the advent of robust crystals of ribosomal 50S subunits, and structural resolution of macrolides and ketolides complexed to either Haloarcula marismortui or Deinococcus radiodurans 50S, the ability to dissect the binding modes and understand resistance at the level of the ribosome became possible. This review article compares the binding features of 14-, 15-, and 16-membered macrolides to that of ketolides telithromycin and ABT-773 as revealed at the atomistic level. Attempts to understand how modifications to 23S rRNA and/or mutations in ribosomal proteins L4 and L22 that have been found to confer resistance in Streptococcus pneumoniae, Streptococcus pyogenes, and Haemophilus influenzae are told from the perspective of the ribosome.
机译：大环内酯类是用于治疗人类呼吸道感染的重要抗生素。尽管这些化合物中的某些已经使用了50年，但直到最近几年才可以更充分地了解它们的作用机理和基于核糖体的耐药性。随着核糖体50S亚基坚固晶体的出现，以及与马氏藻（Haloarcula marismortui）或放射杜鹃（Deinococcus radiodurans）50S结合的大环内酯类和酮类化合物的结构拆分，能够解析结合模式并了解核糖体水平的耐药性。这篇综述文章比较了14、15和16元大环内酯类化合物与酮醇类泰利霉素和ABT-773的结合特性，如在原子水平上所揭示的。试图从核糖体的角度了解如何对23S rRNA的修饰和/或核糖体蛋白L4和L22中的突变赋予肺炎链球菌，化脓性链球菌和流感嗜血杆菌的耐药性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号