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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Perturbation of Macaque Supplementary Motor Area Produces Context-Independent Changes in the Probability of Movement Initiation
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Perturbation of Macaque Supplementary Motor Area Produces Context-Independent Changes in the Probability of Movement Initiation

机译：猕猴补充电机区域的扰动产生了运动启动概率的无关变化

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摘要

The contribution of the supplementary motor area (SMA) to movement initiation remains unclear. SMA exhibits premovement activity across a variety of contexts, including externally cued and self-initiated movements. Yet SMA lesions impair initiation primarily for self-initiated movements. Does SMA influence initiation across contexts or does it play a more specialized role, perhaps contributing only when initiation is less dependent on external cues? To address this question, we perturbed SMA activity via microstimulation at variable times before movement onset. Experiments used two adult male rhesus monkeys trained on a reaching task. We used three contexts that differed regarding how tightly movement initiation was linked to external cues. Movement kinematics were not altered by microstimulation. Instead, microstimulation induced a variety of changes in the timing of movement initiation, with different effects dominating for different contexts. Despite their diversity, these changes could be explained by a simple model where microstimulation has a stereotyped impact on the probability of initiation. Surprisingly, a unified model accounted for effects across all three contexts, regardless of whether initiation was determined more by external cues versus internal considerations. All effects were present for stimulation both contralateral and ipsilateral to the moving arm. Thus, the probability of initiating a pending movement is altered by perturbation of SMA activity. However, changes in initiation probability are independent of the balance of internal and external factors that establish the baseline initiation probability.
机译：补充电机区域（SMA）对运动开始的贡献仍不清楚。 SMA展示各种情况的热敏活动，包括外部被提出和自我发起的运动。然而，SMA病变主要损害起始的自我发起运动。 SMA是否会影响上下文的启动，或者它在发挥更专业的角色，也许只有在开始依赖外部提示时才贡献？为了解决这个问题，我们通过在运动开始前通过微刺痛进行SMA活动。实验使用了两只成年男性恒河猴猴子接受了达到的任务。我们使用了三种情况，这些背景有什么不同的运动启动与外部提示有何相关联。 Microstimulation没有改变运动运动学。相反，微刺激在运动开始时诱导了各种变化，不同的效果为不同的背景。尽管它们多样化，但这些变化可以通过一个简单的模型来解释，其中微刺激对启动概率具有典型的影响。令人惊讶的是，无论外部提示与内部注意事项如何更多地确定，统一模型都占所有三种情况的效果。存在所有效果用于刺激对侧和移动臂的对侧和同侧。因此，通过SMA活性的扰动改变起始运动的启动概率。然而，启动概率的变化与建立基线启动概率的内部和外部因素的余额无关。

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