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首页> 外文期刊>Current opinion in HIV and AIDS >HIV-1 treatment as prevention: the good, the bad, and the challenges.
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HIV-1 treatment as prevention: the good, the bad, and the challenges.

机译：HIV-1治疗可预防：好，坏和挑战。

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PURPOSE OF REVIEW: This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1. RECENT FINDINGS: Two randomized clinical trials demonstrated that antiretroviral agents provided before exposure to HIV-1 offer substantial protection, ostensibly directly proportional to the concentration of antiretroviral therapy (ART) in the genital secretions. Intense focus on the use of HIV treatment as prevention has led to publication of modeling exercises, ecological studies, and observational studies, most of which support the potential benefits of ART. However, the logistical requirements for successful use of ART for prevention are considerable. SUMMARY: ART will serve as a cornerstone of combination prevention of HIV-1. Continued research will be essential to measure anticipated benefits and to detect implementation barriers and untoward consequences of such a program, especially increases in primary ART resistance.
机译：审查目的：这项工作侧重于使用抗逆转录病毒药物来预防HIV-1的性传播。最近的发现：两项随机临床试验表明，在暴露于HIV-1之前提供的抗逆转录病毒药物提供了实质性的保护，表面上与生殖器分泌物中的抗逆转录病毒治疗（ART）浓度直接成正比。对HIV治疗的预防的高度关注导致了建模练习，生态学研究和观察性研究的发表，其中大多数支持ART的潜在益处。但是，成功使用ART进行预防的后勤要求非常可观。简介：ART将作为HIV-1联合预防的基石。继续进行研究对于衡量预期收益并检测该计划的实施障碍和不良后果（尤其是抗ART耐药性增加）至关重要。

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