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首页> 外文期刊>Current opinion in lipidology >Isoflavones: their effects on cardiovascular risk and functions.
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Isoflavones: their effects on cardiovascular risk and functions.

机译：异黄酮：它们对心血管风险和功能的影响。

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PURPOSE OF REVIEW Isoflavones - plant polyphenols with oestrogenic activity - are becoming widely distributed in foods and sold as nutriceuticals. Their similarity to steroidal oestrogens has stimulated research into potential cardiovascular benefits. The two major areas, those of lipid lowering and of improved vascular function, are reviewed.RECENT FINDINGS A major plasma cholesterol lowering effect has not been sustained in recent publications. Relatively minor reductions in LDL-cholesterol or non-HDL-cholesterol have generally been reported, but studies in which no reduction was found have also been reported. Fewer publications have dealt with effects on vasculature, but these have been more consistent. Arterial compliance, a parameter of the elasticity or distensibility of large arteries, is improved by as much as has been reported for estrogens. Vasodilatory effects on the microcirculation with isoflavones or their metabolites may provide opportunities for pharmacological intervention. The metabolism of isoflavones is reviewed briefly in order to highlight its complexity.SUMMARY Although research has failed to demonstrate substantial cholesterol lowering with dietary isoflavones, consumption of legumes is generally to be encouraged as part of the overall strategy for lowering plasma lipids. The favourable effects of ingested or infused isoflavones on several parameters of arterial function suggest an alternative explanation for the apparent low prevalence of coronary disease in populations that eat legumes as a staple food. A better understanding of the pharmacokinetics and bioavailabilty of individual isoflavones is needed if definitive studies are to be designed.
机译：审查的目的异黄酮-具有雌激素活性的植物多酚-正广泛地分布在食品中并作为营养食品出售。它们与类固醇雌激素的相似性刺激了对潜在心血管益处的研究。综述了降低脂质和改善血管功能的两个主要领域。最新发现在最近的出版物中并未持续降低血浆胆固醇的主要作用。 LDL-胆固醇或非HDL-胆固醇的相对较小的减少量已有报道，但也没有发现减少的报道。很少有出版物涉及对脉管系统的影响，但这些更为一致。动脉顺应性是大动脉弹性或扩张性的参数，其改善程度与雌激素的报道一样大。异黄酮或其代谢产物对微循环的血管舒张作用可能为药理干预提供机会。概述了异黄酮的代谢，以突显其复杂性。总结尽管研究未能证明饮食中异黄酮能显着降低胆固醇，但通常应鼓励食用豆类作为降低血浆脂质总体策略的一部分。摄入或注入异黄酮对一些动脉功能参数的有利影响为食用豆类作为主食的人群中冠心病的患病率低提供了另一种解释。如果要进行明确的研究，则需要更好地了解各个异黄酮的药代动力学和生物利用度。

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