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School-age children and adolescents suspected of having been to be infected with pertussis in Japan

机译：学龄儿童和青少年被怀疑在日本被感染百日咳感染

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Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately &90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12-13 years (60.0%. 95%Cl; 56.0-63.9%) in 2014 and 18-19 years (73.0%. 95%Cl; 61.4-82.6%) in 2013, compared with 6-7 years (47.1%. 95%CI; 40.7-53.6%). The mean PT antibody titer was higher among children aged 12-13 years (23.8 95%CI; 21.9-25.8) in 2014 and 18-19 years (29.3 EU/mI. 95%Cl; 23.0-35.6) in 2013, compared with 6-7 years (18.3 EU/mI. 95%Cl; 15.5-21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact. (C) 2018 Elsevier Ltd. All rights reserved.
机译：许多国家在内的日本都有适应的细胞植物疫苗与白喉和破伤风毒素（DTAP）相结合。 DTAP疫苗覆盖率约为＆amp; 90％，自2000年以来，在日本以来已经观察到百日咳重新出现。在本研究中，从2013年到2015年，在学龄儿童和青少年中研究了抗Pertussis抗体。12-13岁儿童的抗Pertussis毒素（Pt）抗体的阳性率高（60.0％。95％ 2014年和18-19岁的CL; 56.0-63.9％（73.0％。95％Cl; 61.4-82.6％），而2013年，而与6-7岁相比（47.1％。95％CI; 40.7-53.6％）。 2014年和18-19岁的12-13岁儿童（23.8 95％CI; 21.9-25.8）的平均Pt抗体滴度较高（29.3 eu / mi。95％cl; 23.0-35.6）相比6-7岁（18.3欧盟/ MI。95％CL; 15.5-21.2）。 Pertussis抗体的分布与他们相同等级的学龄阶级的平均滴度与2013年至2015年相似。虽然学年儿童用4剂DTAP免疫，但数据表明疫苗获得的免疫力衰减和无症状感染的可能性在学龄，表明在小学进入之前的额外DTAP疫苗接种，防止家庭接触。 （c）2018年elestvier有限公司保留所有权利。

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