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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Silver(I) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens
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Silver(I) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens

机译：银（I）与不同的吡啶-4,5-二羧酸盐配体的复合物，作为控制牛乳腺炎相关病原体的有效试剂

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Infections of the cow udder leading to mastitis and lower milk quality are one of the biggest problems in the dairy industry worldwide. Unfortunately, therapeutic options for the treatment of cow mastitis are limited as a consequence of the development of pathogens that are resistant to conventionally used antibiotics. In the search for agents that will be active against cow mastitis associated pathogens, in the present study, five new silver(I) complexes with different chelating pyridine-4,5-dicarboxylate types of ligands, [Ag(NO3)(py-2py)](n) (1), [Ag(NO3)(py-2metz)](n) (2), [Ag(CH3CN)(py-2py)]BF4 (3), [Ag(py-2tz)(2)]BF4 (4) and [Ag(py-2metz)(2)]BF4 (5), py-2py is dimethyl 2,2'-bipyridine-4,5-dicarboxylate, py-2metz is dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate and py-2tz is dimethyl 2-(thiazol-2-yl)pyridine-4,5-dicarboxylate, were synthesized, structurally characterized and assessed for in vitro antimicrobial activity using both standard bioassay and clinical isolates from a contaminated milk sample obtained from a cow with mastitis. These complexes showed remarkable activity against the standard panel of microorganisms and a selection of clinical isolates from the milk of the cow diagnosed with mastitis. With the aim of determining the therapeutic potential of silver(I) complexes, their toxicity in vivo against the model organism, Caenorhabditis elegans (C. elegans), was investigated. The complexes that had the best therapeutic profile, 2 and 5, induced bacterial membrane depolarization and the production of reactive oxygen species (ROS) in Candida albicans cells and inhibited the hyphae as well as the biofilm formation. Taken together, the presented data suggest that the silver(I) complexes with pyridine ligands could be considered for the treatment of microbial pathogens, which are causative agents of cow mastitis.
机译：母牛乳房的感染导致乳腺炎和较低的牛奶品质是全球乳制品行业中最大的问题之一。不幸的是，由于耐常用抗生素的病原体的发展，治疗牛乳腺炎治疗的治疗方案受到限制。在寻找将针对牛乳腺炎相关病原体的药剂中，在本研究中，五种新的银（I）复合物，具有不同螯合吡啶-4,5-二羧酸酯类型的配体，[Ag（No3）（Py-2py ）]（N）（1）和[Ag（NO3）（PY-2metz）]（N）（2）中，将[Ag（CH 3 CN）（PY-2PY）] BF 4（3），将[Ag（PY-2TZ） （2）] BF 4（4）和将[Ag（PY-2metz）（2）] BF 4（5），PY-2PY是二甲基-2,2'-联吡啶-4,5-二羧酸二乙酯，PY-2metz是二甲基-2- （4-甲基噻唑-2-基）吡啶-4,5-二羧酸吡啶-4,5-二羧酸吡啶-4,5-二羧酸二甲基-4,5-二羧酸酯，在体外抗微生物剂中合成，结构表征和评估和评估使用标准生物测定和临床分离物的活性来自牛皮的污染牛奶样品与乳腺炎。这些配合物对微生物标准小组的显着活性以及从诊断患有乳腺炎的母牛的牛奶选择的临床分离物。与确定的银（I）络合物，它们在体内的毒性对抗模式生物，秀丽隐杆线虫（线虫）的治疗潜力的目的，进行了调查。具有最佳治疗型材，2和5，诱导的细菌膜去极化和在念珠菌细胞中的反应性氧物质（ROS）的复合物，并抑制菌丝以及生物膜形成。呈现的数据表明，可以考虑用吡啶配体的银（I）配合物用于治疗微生物病原体，这是母牛乳腺炎的致病剂。

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