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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >NIXANTPHOS: a highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chlorides
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NIXANTPHOS: a highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chlorides

机译：nixantphos：一种高活性配体，用于钯催化的Buchwald-Hartwig胺化的未活化的芳基氯

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摘要

Xantphos is one of the two most common ligands used in palladium catalyzed Buchwald-Hartwig amination reactions, because of its broad scope and high probability of success. It does not, however, work well with unactivated aryl chlorides. Herein NIXANTPHOS is compared to Xantphos and an array of mono- and bidentate phosphines. NIXANTPHOS outperforms Xantphos and all other bidentate ligands examined. Under the optimal reaction conditions, unactivated aryl chlorides afford the expected products in good to excellent yield with as low as 0.05 mol% (500 ppm) palladium loading.
机译：Xantphos是钯催化的Buchwald-Hartwig胺化反应中使用的两个最常见的配体之一，因为其广泛的范围和成功概率高。 然而，它不与未激活的芳基氯共同使用。 在此与Xantphos和一系列单次和二齿磷酸阵列进行比较。 nixantphos优于Xantphos和所有其他双齿配体检查的。 在最佳反应条件下，未活化的芳基氯能够良好地具有优异的产率，低至0.05mol％（500ppm）钯负荷。

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    Mao Jianyou; Zhang Jiadi; Zhang Shuguang; Walsh Patrick J.;

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    Nanjing Tech Univ Jiangsu Natl Synerget Innovat Ctr Adv Mat Sch Chem &

    Mol Engn Inst Adv Synth 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Univ Penn Dept Chem Penn Merck Lab High Throughput Experimentat Roy &

    Diana Vagelos Labs 231 South 34th St Philadelphia PA 19104 USA;

    Univ Penn Dept Chem Penn Merck Lab High Throughput Experimentat Roy &

    Diana Vagelos Labs 231 South 34th St Philadelphia PA 19104 USA;

    Nanjing Tech Univ Jiangsu Natl Synerget Innovat Ctr Adv Mat Sch Chem &

    Mol Engn Inst Adv Synth 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;无机化学;
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