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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Toxicokinetics of HT-2 Toxin in Rats and Its Metabolic Profile in Livestock and Human Liver Microsomes
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Toxicokinetics of HT-2 Toxin in Rats and Its Metabolic Profile in Livestock and Human Liver Microsomes

机译：HT-2毒素在大鼠HT-2毒素的诱导及其在牲畜和人肝微粒体中的代谢谱

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摘要

The lack of information on HT-2 toxin leads to inaccurate hazard evaluations. In the present study, toxicokinetic studies of HT-2 toxin were investigated following intravenous (iv) and oral administration to rats at dosages of 1.0 mg per kilogram of body weight. After oral administration, HT-2 toxin was not detected in plasma, whereas its hydroxylated metabolite, 3'-OH HT-2 was identified. Following iv administration, HT-2 toxin; its 3'-hydroxylated product; and its glucuronide derivative, 3-G1cA HT-2, were observed in plasma, and the glucuronide conjugate was the predominant metabolite. To explore the missing HT-2 toxin in plasma, metabolic studies of HT-2 toxin in liver microsomes were conducted. Consequently, eight phase I and three phase II metabolites were identified. Hydroxylation, hydrolysis, and glucuronidation were the main metabolic pathways, among which hydroxylation was the predominant one, mediated by 3A4, a cytochrome P450 enzyme. Additionally, significant interspecies metabolic differences were observed.
机译：缺乏关于HT-2毒素的信息导致危险评估不准确。在本研究中，在静脉内（IV）和口服给予每千克体重为1.0mg的大鼠的大鼠后，研究了HT-2毒素的毒物动力学研究。口服施用后，在血浆中未检测到HT-2毒素，而其羟基化代谢物，鉴定出3'-OH HT-2。遵循IV管理后，HT-2毒素;它的3'-羟基化产品;其血糖醛酸衍生物3-G1CA HT-2在血浆中观察，葡萄糖醛酸缀合物是主要的代谢物。为了探讨血浆中缺失的HT-2毒素，进行了HT-2毒素在肝微粒体中的代谢研究。因此，鉴定了八相和三相代谢物。羟基化，水解和葡糖醛化是主要代谢途径，其中羟基化是主要的一种，由3A4介导的细胞色素P450酶。此外，观察到显着的筛选差异。

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  • 作者

    Yang Shupeng; Zhang Huiyan; De Boevre Marthe; Zhang Jinzhen; Li Yanshen; Zhang Suxia; De Saeger Sarah; Zhou Jinhui; Li Yi; Sun Feifei;

  • 作者单位

    Chinese Acad Agr Sci Minist Agr Bee Prod Qual Supervis &

    Testing Ctr Beijing 100093 Peoples R China;

    Univ Ghent Fac Pharmaceut Sci Lab Food Anal Ottergemsesteenweg 460 B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Food Anal Ottergemsesteenweg 460 B-9000 Ghent Belgium;

    Univ Ghent Fac Pharmaceut Sci Lab Food Anal Ottergemsesteenweg 460 B-9000 Ghent Belgium;

    Yantai Univ Coll Life Sci Yantai 264005 Shandong Peoples R China;

    China Agr Univ Coll Vet Med Beijing 100193 Peoples R China;

    Univ Ghent Fac Pharmaceut Sci Lab Food Anal Ottergemsesteenweg 460 B-9000 Ghent Belgium;

    Chinese Acad Agr Sci Minist Agr Bee Prod Qual Supervis &

    Testing Ctr Beijing 100093 Peoples R China;

    Chinese Acad Agr Sci Minist Agr Bee Prod Qual Supervis &

    Testing Ctr Beijing 100093 Peoples R China;

    Chinese Acad Agr Sci Minist Agr Bee Prod Qual Supervis &

    Testing Ctr Beijing 100093 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    bioavailability; metabolism; phenotype; mycotoxin; risk assessment;

    机译：生物利用度;新陈代谢;表型;霉菌毒素;风险评估;

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