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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Feruloylated Oligosaccharides Alleviate Dextran Sulfate Sodium-Induced Colitis in Vivo
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Feruloylated Oligosaccharides Alleviate Dextran Sulfate Sodium-Induced Colitis in Vivo

机译：过硫化的寡糖可缓解硫酸葡聚糖钠诱导的结肠炎

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摘要

The imbalance of T lymphocyte subsets substantially conduces to disturbed intestinal immune system and succeeding colonic tissue damage in inflammatory bowel diseases. It is considered that regulation of phytochemicals on cytokine production potentially provides a broad prospect for the exploitation of immunomodulatory agents. Here, we reported that oral administration of feruloylated oligosaccharides (FOs) effectively alleviated mice colitis disease induced by dextran sulfate sodium (DSS). FOs decreased the percentage of T helper (Th)17 cells and downregulated the production of Th17-specific cytokines. In contrast, FOs increased the percentage of regulatory T (Treg) cells and elevated the production of Treg-specific cytokines in colons of DSS-challenged mice. These results indicated that FOs restored the immunologic equilibrium of Th17 and Treg subsets, hereby ameliorating the deterioration of colitis. Furthermore, FOs diminished the secretion of interleukin (IL)-23 and IL-6 but enhanced the transforming growth factor-beta 1 (TGF-beta 1) in dendritic cells in vitro and in vivo, which contributed to the restoration of Th17 and Treg cells immune balance. The mechanistic analysis showed that the regulation of FOs on IL-23 and IL-6 was associated with the nuclear factor-kappa-gene binding signaling pathway and TGF-beta 1 with mitogen-activated protein kinase-activator protein 1 signaling pathway. Taken together, oral administration of FOs exerted potent immunomodulatory effects against mice colitis via restoring the immune balance of Th17 and Treg cells.
机译：T淋巴细胞亚群的不平衡显着涉及令人不安的肠免疫系统，并且在炎性肠病中枢结肠组织损伤。认为，对细胞因子生产的植物化学性的调节可能是对免疫调节剂的开采的广阔前景。在这里，我们报道了经氧化铁糖醛糖（FOS）的口服施用，有效地减轻了硫酸葡聚糖钠（DSS）诱导的小鼠结肠炎病。 FOS减少了T辅助杆（TH）17细胞的百分比，并下调了Th17特异性细胞因子的产生。相反，FOS增加了调节性T（Treg）细胞的百分比，并升高了DSS攻击小鼠的冒号中Treg特异性细胞因子的产生。这些结果表明FOS恢复了Th17和Treg子集的免疫平衡，从而改善结肠炎的恶化。此外，FOS减少了白细胞介素（IL）-23和IL-6的分泌，但在体外和体内增强了树突细胞中的转化生长因子-β1（TGF-β1），这有助于恢复Th17和Treg细胞免疫平衡。机械分析表明，IL-23和IL-6上的FOS调节与核因子-Kappa-基因结合信号通路和TGF-β1与丝裂原激活的蛋白激酶激活蛋白1信号传导途径有关。在一起，通过恢复Th17和Treg细胞的免疫平衡，对小鼠结肠炎的有效免疫调节作用施加有效免疫调节作用。

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    Xia Xichun; Zhu Leqing; Lei Zhiwei; Song Yueqi; Tang Fen; Yin Zhao; Wang Jing; Huang Junqing;

  • 作者单位

    Jinan Univ Biomed Translat Res Inst Affiliated Hosp 1 Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Biomed Translat Res Inst Affiliated Hosp 1 Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Biomed Translat Res Inst Affiliated Hosp 1 Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Biomed Translat Res Inst Affiliated Hosp 1 Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Biomed Translat Res Inst Affiliated Hosp 1 Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Tradit Chinese Med Formula Pattern Res Ctr Guangzhou 510632 Guangdong Peoples R China;

    Beijing Technol &

    Business Univ Beijing Engn &

    Technol Res Ctr Food Addit Beijing 100048 Peoples R China;

    Jinan Univ Coll Tradit Chinese Med Formula Pattern Res Ctr Guangzhou 510632 Guangdong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    feruloylated oligosaccharide; dendritic cells; Th17 cells; Treg cells; colitis;

    机译：Feruloylated寡糖;树突细胞;Th17细胞;Treg细胞;结肠炎;

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