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首页> 外文期刊>Journal of Neurophysiology >Pupil-linked arousal modulates behavior in rats performing a whisker deflection direction discrimination task
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Pupil-linked arousal modulates behavior in rats performing a whisker deflection direction discrimination task

机译：瞳孔连接的唤醒在执行晶须偏转方向歧视任务的大鼠中调节行为

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摘要

Non-luminance-mediated changes in pupil size have been widely used to index arousal state. Recent animal studies have demonstrated correlations between behavioral state-related pupil dynamics and sensory processing. However, the relationship between pupil-linked arousal and behavior in animals performing perceptual tasks has not been fully elucidated. In the present study, we trained head-fixed rats to discriminate between directions of whisker movements using a Go/No-Go discrimination paradigm while imaging their pupils. Reaction times in this discrimination task were significantly slower than in previously reported detection tasks with similar setup, suggesting that discrimination required an increased cognitive load. We found the pupils dilated for all trials following stimulus presentation. Interestingly, in correct rejection trials, where pupil dilations solely resulted from cognitive processing, dilations were larger for more difficult stimuli. Baseline pupil size before stimulus presentation strongly correlated with behavior, as perceptual sensitivity peaked at intermediate pupil baselines and reaction time was fastest at large baselines. We further explored these relationships by investigating to what extent pupil baseline was predictive of upcoming behavior and found that a Bayesian decoder had significantly greater-than-chance probability in correctly predicting behavioral outcomes. Moreover, the outcome of the previous trial showed a strong correlation with behavior on present trials. Animals were more liberal and faster in responding following hit trials, whereas perceptual sensitivity was greatest following correct rejection trials. Taken together, these results suggest a tight correlation between pupil dynamics. perceptual performance, and reaction time in behaving rats, all of which are modulated by fluctuating arousal state.
机译：非亮度介导的瞳孔大小的变化已被广泛用于指令唤醒状态。最近的动物研究表明了行为状态相关的瞳孔动力学和感官加工之间的相关性。然而，瞳孔关联的唤醒与表演感知任务的动物行为之间的关系尚未完全阐明。在本研究中，我们训练了头固定的大鼠，以在对学生成像时使用GO / NO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-GO-Go-Go ispimation的方向区分。在这种歧视任务中的反应时间比以前报告的检测任务在具有相似的设置中显着慢，表明歧视需要增加的认知载荷。我们发现刺激介绍后所有试验扩张的学生。有趣的是，在正确的抑制试验中，在瞳孔扩张仅由认知加工引起的情况下，对于更困难的刺激，扩张较大。基线瞳孔大小在刺激介绍与行为强烈相关，因为在中间瞳孔基线上达到的感知敏感性，并且在大型基线上最快的反应时间最快。我们进一步通过调查瞳孔基线预测即将到来的行为的程度，发现贝叶斯解码器在正确预测行为结果方面具有明显大于机会概率的程度。此外，先前试验的结果表明与目前试验的行为有着强烈的相关性。在打击试验后，动物更加自由，更快地更快地响应，而感知敏感性是最大的抑制试验。总之，这些结果表明瞳孔动力学之间的相关性紧张。感知性能和表现大鼠的反应时间，所有这些都是通过波动的唤醒状态调节的。

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