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首页> 外文期刊>Academic radiology >Diffusion-weighed MR of the thyroid gland in Graves' disease: assessment of disease activity and prediction of outcome.
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Diffusion-weighed MR of the thyroid gland in Graves' disease: assessment of disease activity and prediction of outcome.

机译：格雷夫斯病甲状腺的弥散加权MRI：疾病活动性评估和结果预测。

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RATIONALE AND OBJECTIVES: To assess the activity and clinical course of Graves' disease with diffusion-weighted magnetic resonance (MR) imaging. MATERIALS AND METHODS: Fifty-one patients with Graves' disease and 25 volunteers underwent diffusion MR imaging of the thyroid gland using a single shot echo-planar imaging with b-factor of 0, 300 and 600 second/mm(2). The apparent diffusion coefficient (ADC) values of the thyroid gland were calculated. Patients with active Graves' disease included untreated patients at initial diagnosis (n = 12), patients under antithyroid drugs (n = 11), and patients in relapse after withdrawal of therapy (n = 13). Patients with inactive disease had a remission of hyperthyroidism (n = 15). RESULTS: The mean ADC values of thyroid gland with active Graves' disease was 0.65 +/- 0.03 x 10(-3) mm(2)/second in patients at initial diagnosis, 0.81 +/- 0.02 x 10(-3) mm(2)/second in patients undergoing antithyroid drug and 0.72 +/- 0.07 x 10(-3) mm(2)/second in patients with relapse of hyperthyroidism. The mean ADC of patients with remission was 0.94 +/- 0.03 x 10(-3) mm(2)/second and for normal volunteer was 1.06 +/- 0.08 x 10(-3) mm(2)/second. There was significant difference in the ADC value of patients with active disease and remission (P = .001). The cutoff ADC value used for differentiating patients with active disease from patients with remission was 0.82 x 10(-3) mm(2)/second. The mean ADC value of thyroid gland had positive correlation with thyroid-stimulating hormone (r = 0.87, P = .001) and negative correlation with serum T4 (r = -0.82, P = .001) and serum T3 (r = -0.71, P = .001). CONCLUSIONS: The ADC value of the thyroid gland is a promising non invasive parameter for diagnosis of different clinical stages of Graves' disease. Hence it can be used to assess the activity and predict the outcome of patients during and after medical treatment.
机译：理由和目的：用弥散加权磁共振（MR）成像评估Graves病的活动和临床过程。材料与方法：51名Graves病患者和25名志愿者使用b因子为0、300和600秒/ mm（2）的单次回波平面成像对甲状腺进行了弥散MR成像。计算甲状腺的表观扩散系数（ADC）值。患有活动性Graves病的患者包括初诊时未经治疗的患者（n = 12），使用抗甲状腺药物的患者（n = 11）和停药后复发的患者（n = 13）。非活动性疾病患者甲状腺功能亢进症缓解（n = 15）。结果：初诊时患有活动性Graves病的甲状腺平均ADC值为0.65 +/- 0.03 x 10（-3）mm（2）/秒，0.81 +/- 0.02 x 10（-3）mm接受抗甲状腺药物治疗的患者为（2）/秒，甲状腺功能亢进复发的患者为0.72 +/- 0.07 x 10（-3）mm（2）/秒。缓解患者的平均ADC为0.94 +/- 0.03 x 10（-3）mm（2）/秒，正常志愿者为1.06 +/- 0.08 x 10（-3）mm（2）/秒。患有活动性疾病和缓解的患者的ADC值存在显着差异（P = .001）。用于区分活动性疾病患者和缓解期患者的临界ADC值为0.82 x 10（-3）mm（2）/秒。甲状腺的ADC平均值与促甲状腺激素呈正相关（r = 0.87，P = .001），与血清T4（r = -0.82，P = .001）和血清T3（r = -0.71）呈负相关。 ，P = 0.001）。结论：甲状腺的ADC值是诊断Graves病不同临床阶段的有前途的非侵入性参数。因此，它可以用于评估治疗过程中和治疗后的活动并预测患者的预后。

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