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首页> 外文期刊>Acta biomaterialia >On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics.
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On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics.

机译：关于纳米晶铁氧体作为药物输送的磁性载体的适用性：功能化，共轭和药物释放动力学。

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摘要

Superparamagnetic nickel ferrite nanoparticles functionalized with polyvinyl alcohol, polyethylene oxide and polymethacrylic acid (PMAA) polymers and subsequently conjugated with doxorubicin anti-cancer drug are studied for their use as a magnetic carrier for drug delivery. Fourier transform infrared spectroscopy enabled examination of the ability of the nanoparticles to be functionalized with polymers and conjugated with doxorubicin drug. The functionalized polymer-coated nanocrystalline nickel ferrites retain the magnetic characteristics of non-functionalized nanocrystalline nickel ferrites (superparamagnetism, absence of hysteresis, remanence and coercivity at room temperature), encouraging their application as a magnetic carrier for drug delivery. The PMAA-coated nanoferrites are demonstrated as being a potentially superior magnetically targeted drug carrier based on FTIR results and drug release kinetics in the absence and presence of an external magnetic field.
机译：研究了用聚乙烯醇，聚环氧乙烷和聚甲基丙烯酸（PMAA）聚合物官能化并随后与阿霉素抗癌药物缀合的超顺磁性镍铁氧体纳米粒子作为药物递送的磁性载体的用途。傅里叶变换红外光谱能够检查纳米颗粒被聚合物官能化并与阿霉素药物结合的能力。官能化的聚合物涂覆的纳米晶镍铁氧体保留了非官能化的纳米晶镍铁氧体的磁性（超顺磁性，无磁滞，剩磁和室温下的矫顽力），从而促进了它们作为药物递送的磁性载体的应用。基于FTIR结果和在不存在和存在外部磁场的情况下的药物释放动力学，基于PMAA涂层的纳米铁氧体被证明是潜在的磁性靶向药物载体。

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