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首页> 外文期刊>Acta biomaterialia >Hydroxyapatite/biodegradable poly(L-lactide-co-epsilon-caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route.
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Hydroxyapatite/biodegradable poly(L-lactide-co-epsilon-caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route.

机译：羟基磷灰石/可生物降解的聚（L-丙交酯-ε-己内酯）复合微粒通过皮克林（Pickering）乳液路线作为可注射支架。

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摘要

Hydroxyapatite (HAp)/biodegradable poly(L-lactide-co-epsilon-caprolactone) (P(LA/CL)) composite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants. A stable oil in water emulsion was obtained using water dispersed HAp nanocrystals as the particulate emulsifier and a dichloromethane (CH(2)Cl(2)) solution of P(LA/CL) as the oil phase. The concentration-viscosity relationship of the P(LA/CL) solution and its influence on the formation of a stable emulsion were investigated. The dependence of homogenization on the concentration of the P(LA/CL) solution and shear speed of homogenization was also evaluated. HAp/P(LA/CL) microparticles of various morphologies, such as plates and spheres, or with various surface morphologies were realized through adjustment of the concentration and composition of the P(LA/CL) solution. The microparticles were observed by optical microscopy and scanning electronic microscopy and their size distributions measured using a microparticle size analyzer. The weight percentages of HAp nanocrystals on the HAp/P(LA/CL) microparticles of different average sizes were measured by thermogravimetric analysis.
机译：在没有任何分子表面活性剂的情况下，通过Pickering乳液途径将羟基磷灰石（HAp）/可生物降解的聚（L-丙交酯-ε-己内酯）（P（LA / CL））复合微粒制成可注射支架。使用水分散的HAp纳米晶体作为颗粒乳化剂，并使用P（LA / CL）的二氯甲烷（CH（2）Cl（2））溶液作为油相，可以获得稳定的水包油乳液。研究了P（LA / CL）溶液的浓度-粘度关系及其对稳定乳液形成的影响。还评估了均质化对P（LA / CL）溶液浓度和均质化剪切速度的依赖性。通过调节P（LA / CL）溶液的浓度和组成，可以得到各种形态的HAp / P（LA / CL）微粒，例如板和球，或具有各种表面形态。通过光学显微镜和扫描电子显微镜观察微粒，并使用微粒尺寸分析仪测量其尺寸分布。通过热重分析法测量不同平均尺寸的HAp / P（LA / CL）微粒上HAp纳米晶体的重量百分比。

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