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首页> 外文期刊>Acta biomaterialia >Osmotic cavitation of elastomeric intraocular lenses.
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Osmotic cavitation of elastomeric intraocular lenses.

机译：弹性人工晶状体的渗透空化。

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摘要

In recent years, traditional rigid materials have been replaced with softer elastomers in intraocular lenses to minimize the size of the required surgical incision, thereby reducing patient recuperation time. However, water-filled cavities that may impact visual acuity are found in many of these new implants. We demonstrate that the cavitation observed in vivo can occur due to an osmotic pressure difference between the aqueous solution within the cavity and the external media in which the lens is immersed. By reducing the osmolarity of the external solution from 300 to 0mM, we observe an increase in cavity volume of almost a factor of 30. Further, we have developed a model for cavity growth assuming the controlling factor is diffusion of hydrophilic molecules from the polymer matrix into the cavity. We find that the experimental observations are consistent with the model and suggest that oligomeric species generated during polymerization are responsible for the observed cavitation.
机译：近年来，传统的刚性材料已被人工晶状体中的较软弹性体所取代，以最大程度地减少所需手术切口的尺寸，从而减少了患者的休养时间。但是，在许多这些新植入物中发现了可能会影响视敏度的充满水的空腔。我们证明体内观察到的气蚀现象可能是由于空腔内的水溶液与浸入晶状体的外部介质之间的渗透压差引起的。通过将外部溶液的渗透压从300mM降低到0mM，我们观察到腔体积的增加几乎是30倍。此外，我们假设控制因素是亲水性分子从聚合物基体中扩散出来，从而开发了腔增长模型。进入空腔。我们发现实验观察结果与模型一致，并表明在聚合过程中产生的低聚物质是造成观察到的空化的原因。

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