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首页> 外文期刊>Acta biomaterialia >In vitro dissolution and mechanical behavior of c-axis preferentially oriented hydroxyapatite thin films fabricated by pulsed laser deposition.
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In vitro dissolution and mechanical behavior of c-axis preferentially oriented hydroxyapatite thin films fabricated by pulsed laser deposition.

机译：通过脉冲激光沉积制备的c轴优先取向羟基磷灰石薄膜的体外溶解和力学行为。

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Owing to its resemblance to the major inorganic constituent of bone and tooth, hydroxyapatite is recognized as one of the most biocompatible materials and is widely used in systems for bone replacement and regeneration. In this study the pulsed laser deposition technique was chosen to produce hydroxyapatite with different crystallographic orientations in order to investigate some of the material properties, including its in vitro dissolution behavior, as well as mechanical properties. The crystallographic orientations of hydroxyapatite coatings can be carefully controlled, mainly by varying the energy density of the KrF excimer laser (248 nm) used for deposition. Nanoindentation results showed that highly c-axis oriented hydroxyapatite coatings have higher hardness and Young's modulus values compared with the values of randomly oriented coatings. After 24h immersion in simulated physiological solution the overall surface morphology of the highly oriented coatings was dramatically altered. The porosity was drastically increased and sub-micron pores were formed throughout the coatings, whereas the average size of the grains in the coatings was not significantly changed. The composition of the textured hydroxyapatite coatings remained essentially unchanged. Their c-axis texture, on the other hand, was rather enhanced with an increase in immersion time. The c-axis oriented hydroxyapatite surfaces are likely to promote preferentially oriented growth through a cyclic process of dissolution and reprecipitation, followed by homoepitaxial growth. The remarkable morphological and microstructural changes after dissolution suggest a capability of highly textured hydroxyapatite as a tissue engineering scaffold with an interconnecting porous network that may be beneficial for cellular activity.
机译：由于羟基磷灰石与骨骼和牙齿的主要无机成分相似，因此被认为是生物相容性最高的材料之一，被广泛用于骨骼置换和再生的系统中。在这项研究中，选择脉冲激光沉积技术来生产具有不同晶体学取向的羟基磷灰石，以研究某些材料性能，包括其体外溶解行为以及机械性能。羟基磷灰石涂层的晶体学取向可以通过使用用于沉积的KrF受激准分子激光器（248 nm）的能量密度变化来仔细控制。纳米压痕结果表明，与无规取向涂层相比，高c轴取向羟基磷灰石涂层具有更高的硬度和杨氏模量值。在模拟生理溶液中浸泡24小时后，高度取向涂层的整体表面形态发生了巨大变化。孔隙率急剧增加，并且在整个涂层中形成了亚微米的孔，而涂层中晶粒的平均尺寸没有明显变化。织构的羟基磷灰石涂层的组成基本上保持不变。另一方面，它们的c轴纹理随着浸入时间的增加而得到了增强。 c轴取向的羟基磷灰石表面很可能通过溶解和再沉淀的循环过程促进同向外延生长的优先取向生长。溶解后显着的形态和微观结构变化表明，高度织构的羟基磷灰石具有作为组织工程支架的能力，具有相互连接的多孔网络，可能对细胞活性有益。

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