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首页> 外文期刊>Acta biomaterialia >Advantages of bilayered vascular grafts for surgical applicability and tissue regeneration.
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Advantages of bilayered vascular grafts for surgical applicability and tissue regeneration.

机译：双层血管移植物在手术应用和组织再生方面的优势。

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Nanofibrous scaffolds are part of an intense research effort to design the next generation of vascular grafts. With electrospinning, the production of micro- and nano-fiber-based prostheses is simple and cost effective. An important parameter for tissue regeneration in such scaffolds is pore size. Too small pores will impede cell infiltration, but too large pores can lead to problems such as blood leakage. In this study, bilayered grafts were made by electrospinning a high-porosity graft with a low-porosity layer on either the luminal or the adventitial side. Grafts were characterized in vitro for fiber size, pore size, total porosity, water and blood leakage, mechanical strength, burst pressure and suture retention strength, and were evaluated in vivo in the rat abdominal aorta replacement model for 3 and 12 weeks. In vitro blood leakage through these bilayered grafts was significantly reduced compared with a high-porosity graft. All grafts had an excellent in vivo outcome, with perfect patency and no thrombosis. Cell invasion and neovascularization were significantly reduced in the grafts with a low-porosity layer on the adventitial side, and there was no significant difference between the grafts in endothelialization rate or intimal hyperplasia. By tailoring the microarchitecture of biodegradable vascular prostheses, it is therefore possible to optimize the scaffold for tissue regeneration while preventing blood leakage, and thus facilitating applicability in the clinic.
机译：纳米纤维支架是设计下一代血管移植物的一项深入研究工作的一部分。通过静电纺丝，生产基于微纤维和纳米纤维的假体既简单又经济。在这种支架中用于组织再生的重要参数是孔径。毛孔太小会阻碍细胞浸润，但毛孔太大会导致血液渗漏等问题。在这项研究中，通过电纺在腔侧或外膜侧具有低孔隙率层的高孔隙率移植物制成双层移植物。在体外对移植物进行了纤维大小，孔径，总孔隙率，水和血液渗漏，机械强度，破裂压力和缝合线保持强度的表征，并在大鼠腹主动脉置换模型中进行了3周和12周的体内评估。与高孔隙率移植物相比，通过这些双层移植物进行的体外血液泄漏明显减少。所有移植物均具有出色的体内结果，通畅性好，无血栓形成。在外膜侧具有低孔层的移植物中，细胞侵袭和新血管形成显着减少，并且移植物之间的内皮化速率或内膜增生没有明显差异。通过定制可生物降解的血管假体的微体系结构，因此可以优化用于组织再生的支架，同时防止血液泄漏，从而促进在临床上的适用性。

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