• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Biodegradation of metallic magnesium elicits an inflammatory response in primary nasal epithelial cells.
【24h】

Biodegradation of metallic magnesium elicits an inflammatory response in primary nasal epithelial cells.

机译：金属镁的生物降解引起鼻上皮细胞的炎症反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Resorbable magnesium-based implants hold great promise for various biomedical applications, such as osteosynthesis and coronary stenting. They also offer a new therapeutic option for the treatment of chronic rhinosinusitis, but little data is yet available regarding the use of magnesium in the nasal cavity. To model this field of application, primary porcine nasal epithelial cells were used to test the biocompatibility of degrading pure magnesium and investigate whether the degradation products may also affect cellular metabolism. Magnesium specimens did not induce apoptosis and we found no major influence on enzyme activities or protein synthesis, but cell viability was reduced and elevated interleukin 8 secretion indicated proinflammatory reactions. Necrotic damage was most likely due to osmotic stress, and our results suggest that magnesium ion build-up is also involved in the interleukin 8 release. Furthermore, the latter seems to be mediated, at least in part, by the p38 signaling pathway. These effects probably depended on the accumulation of very high concentrations of magnesium ions in the in vitro set-up, which might not be achieved in vivo, although we cannot exclude that further, as yet unknown, factors played a role in the inflammatory response during the degradation process. In conclusion, the biocompatibility of pure magnesium with cells in the immediate vicinity appears less ideal than is often supposed, and this needs to be considered in the evaluation of magnesium materials containing additional alloying elements.
机译：可吸收的镁基植入物在各种生物医学应用中具有广阔的前景，例如骨合成和冠状动脉支架植入术。它们还为慢性鼻-鼻窦炎的治疗提供了新的治疗选择，但有关鼻腔中镁的使用的数据尚少。为了模拟这一应用领域，猪原代鼻上皮细胞被用于测试降解纯镁的生物相容性，并研究降解产物是否也可能影响细胞代谢。镁标本没有诱导细胞凋亡，我们发现对酶活性或蛋白质合成没有重大影响，但是细胞活力降低并且白介素8分泌升高表明促炎反应。坏死很可能是由于渗透压引起的，我们的结果表明镁离子的积累也与白介素8的释放有关。此外，后者似乎至少部分地由p38信号传导途径介导。这些影响可能取决于体外设置中镁离子的高浓度积累，这在体内可能无法实现，尽管我们不能排除进一步（至今未知）因素在炎症过程中发挥炎症反应的作用。降解过程。总之，纯镁与紧邻细胞的生物相容性似乎不如通常所想的理想，因此在评估含有其他合金元素的镁材料时需要考虑这一点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号