Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones

Wu Liqiang; Zhang Chong

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Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones

机译：新型替代5H-苯并[1,3,4]噻唑啉-6,7-致力的新型替代5H-苯并[1,3,4]

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A series of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones, designed via a molecular hybridization approach, were synthesized in very good yields using one-pot condensation of 2-hydroxy-1,4-naphthoquinone, aldehydes, and 5-substituted-2-amino-1,3,4-thiadiazole. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines (HCT116 and HepG2), and the results showed that most of the new compounds showed good to potent cytotoxic activities.

机译：通过分子杂交方法设计的一系列新型取代的5H-苯并[1,3,4]噻唑啉-6,7-致力于使用单一的产率合成，使用一个 - 罐凝结的2-羟基-1,4-萘醌，醛和5取代-2-氨基-1,3,4-噻二唑。所有合成化合物的抗肿瘤活性在两种不同的人类癌细胞系（HCT116和HepG2）上评估，结果表明，大多数新化合物对有效的细胞毒性活动良好。

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《RSC Advances》 |2016年第34期|共8页
作者
Wu Liqiang; Zhang Chong;
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Xinxiang Med Univ Sch Pharm Xinxiang 453003 Peoples R China;

Xinxiang Med Univ Sch Pharm Xinxiang 453003 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones [J] . Wu Liqiang, Zhang Chong RSC Advances . 2016,第34期

机译：新型替代5H-苯并[1,3,4]噻唑啉-6,7-致力的新型替代5H-苯并[1,3,4]
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机译：新型萘并[2,1-b]呋喃-5H- [3,2-d] [1,3,4]噻二唑并[3,2-a]嘧啶-5-酮的合成及抗菌活性

Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones

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