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首页> 外文期刊>RSC Advances >DOX-Fe3O4@mSiO(2)-PO-FA nanocomposite for synergistic chemo- and photothermal therapy
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DOX-Fe3O4@mSiO(2)-PO-FA nanocomposite for synergistic chemo- and photothermal therapy

机译：DOX-FE3O4 @ MSIO（2）-PO-FA纳米复合材料，用于协同化学和光热疗

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摘要

The integration of multiple therapies into one nanoplatform was considered to be the most efficient method to give an enhanced therapeutic effect for anti-cancer treatments. In this research, pH sensitive drug release and near-infrared (NIR)-induced photothermal therapy (PTT) were placed in one nanocomposite using iron(II,III) oxide@meso-silica (Fe3O4@mSiO(2)) NPs as the host. Then, a sensitive ketal modified silane coupling agent (PO linker) was prepared to encapsulate the anticancer drug, doxorubicin hydrochloride (DOX), into the mSiO(2) shell, ensuring the few leakage. Based on the different pH conditions of normal and cancer cells, the DOX-Fe3O4@mSiO(2)-PO nanocomposite exhibits the specific drug release in cancer cells (acid conditions) before that the few leakage makes sure there are a low number of side effects. Furthermore, the release kinetics can also be easily adjusted by varying the amount of PO linker. Under NIR (808 nm) irradiation, the photothermal effect derived from magnetic Fe3O4 NPs can also induce the apoptosis of the cancer cells which is how PTT is achieved. HeLa cells (cervical cancer cell line) were used as the typical cancer cell and the detailed cell experiments further display the enhanced specific cytotoxicity of the method to HeLa cells. The multifunctional nanocomposite has great potential as an application for anti-cancer therapy.
机译：将多种疗法的整合到一个纳米甲型形成中被认为是给予抗癌治疗增强治疗效果的最有效的方法。在该研究中，使用铁（II，III）氧化物（Fe3O4 @ MSIO（2））NPS将pH敏感药物释放和近红外（NIR）诱导的光热疗（PTT）置于一个纳米复合物中（FE3O4 @ MSIO（2））NPS主持人。然后，制备敏感的氯化物改性硅烷偶联剂（PO接头）将抗癌药物，盐酸盐素（DOX）包封在MSIO（2）壳中，确保少量泄漏。基于正常和癌细胞的不同pH条件，DOX-FE3O4 @ MSIO（2）-PO纳米复合材料在近少年的泄漏确保侧面较少之前表现出癌细胞（酸条件）中的特定药物释放效果。此外，还可以通过改变PO接头量来容易地调节释放动力学。在NIR（808nm）照射下，源自磁Fe3O4 NPS的光热效应也可以诱导癌细胞的凋亡，这是如何实现PTT的凋亡。使用HeLa细胞（宫颈癌细胞系）作为典型的癌细胞，并且详细的细胞实验进一步显示了对HeLa细胞的增强的特异性细胞毒性。多功能纳米复合材料具有巨大的潜力作为抗癌治疗的应用。

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  • 来源
    《RSC Advances》 |2016年第113期|共9页
  • 作者

    Luo Xiangjie; Wang Ying; Lin Huiming; Qu Fengyu;

  • 作者单位

    Harbin Normal Univ Coll Chem &

    Chem Engn Harbin 150025 Peoples R China;

    Harbin Normal Univ Coll Chem &

    Chem Engn Harbin 150025 Peoples R China;

    Harbin Normal Univ Coll Chem &

    Chem Engn Harbin 150025 Peoples R China;

    Harbin Normal Univ Coll Chem &

    Chem Engn Harbin 150025 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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