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Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects

机译：IL6基因多态性与肥胖对象代谢综合征组分特征的关联

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摘要

Metabolic syndrome (MetS) is a risk factor for type 2 diabetes mellitus and cardiovascular disease. Obesity is a component of the metabolic syndrome. Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. Since obesity is associated with inflammatory factors, the aim of this study was to investigate the association between this polymorphism and MetS and its related features. Obese patients with body mass index (BMI) >= 30 (n = 182) were recruited into this study and divided into two groups; 110 patients with MetS, based on the International Diabetes Federation (IDF) criteria, and 72 subjects without MetS. The anthropometric and biochemical data for the groups were compared. Genotyping was carried out using RT-PCR. The association of the genetic polymorphism with MetS and its components were assessed using univariate and multivariate analyzes. There was an association between the presence of the rs1800796polymorphism of the IL-6 gene, with BMI (P = 0.031), high-density lipoprotein (HDL) (P = 0.010) and low-density lipoprotein (LDL) (P = 0.037), while this genetic variant did not show any significant association with the presence of MetS as defined by the IDF. We demonstrate an association between the rs1800796 genetic variant of the IL-6 gene with components of MetS including BMI, and HDL-cholesterol, but not the MetS itself. Therefore, supporting further studies are warranted to investigate this point in a larger population.
机译：代谢综合征（METS）是2型糖尿病和心血管疾病的危险因素。肥胖是代谢综合征的组成部分。据报道，几种遗传变体与肥胖症和Hypo脂联蛋白血症相关，包括白细胞介素-6（IL-6）基因的ARS1800796多态性。由于肥胖与炎症因素有关，因此该研究的目的是研究这种多态性和核苷酸之间的关联及其相关特征。患有体重指数（BMI）> = 30（n = 182）的肥胖患者被募集到本研究中并分为两组; 110名核心患者，基于国际糖尿病联合会（IDF）标准，72名受试者没有必要型。比较了组的人类测定和生化数据。基因分型使用RT-PCR进行。使用单变量和多变量分析评估遗传多态性与Mets及其组分的关联。在IL-6基因的RS1800796聚物存在之间存在关联，具有BMI（P = 0.031），高密度脂蛋白（HDL）（P = 0.010）和低密度脂蛋白（LDL）（P = 0.037） ，虽然该遗传变异没有显示任何与IDF所定义的Mets的存在关系。我们展示了IL-6基因的RS1800796遗传变异与Mets的组分之间的关​​联，包括BMI和HDL-胆固醇，但不是Mets本身。因此，有必要支持进一步的研究来调查较大人群的这一点。

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