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首页> 外文期刊>Biochemical Genetics >Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3
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Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3

机译：Sysicic Lupus红斑狼疮和类风湿性关节炎CYP3A5 * 3 / * 3患者的血液浓度的性差异

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摘要

The purpose of this study was to describe the impact of sex and cytochrome P450 3A5 (CYP3A5) variant on the blood concentration of tacrolimus in patients with systemic lupus erythematosus or rheumatoid arthritis. The blood concentration of tacrolimus (ng/mL) divided by the daily dose of tacrolimus (mg/day) and the patient's weight (kg) (C/D) was obtained from 55 patients. The C/D value was analysed according to genetic variation in CYP3A5 or ATP binding cassette subfamily B member 1 (ABCB1), sex, and age. The C/D value in the CYP3A5*3/*3 group was significantly higher than in the CYP3A5*1/*1 and *1/*3 groups (p < 0.05, effect size: d = 1.40). In the CYP3A5*3/*3 group, the concentration of tacrolimus was significantly higher in men than in women (p < 0.05, effect size: d = 1.78). Furthermore, in the CYP3A5*3/*3 group, the concentration of tacrolimus was significantly higher in women aged over 50 years than in women aged under 50 years (p < 0.05, effect size: d = 1.18). In contrast, ABCB1 genetic variations did not show any significant effect on the C/D value. Since the blood concentration of tacrolimus in patients with CYP3A5*3/*3 varies depending on sex and age, these factors should be considered when studying the difference of sex in CYP3A.
机译：本研究的目的是描述性别和细胞色素P450 3A5（CYP3A5）变体对系统性红斑狼疮或类风湿性关节炎患者血液浓度的影响。从55例患者中获得了每日躯干（Mg /天）和患者的重量（kg）（c / d）的日常剂量的血液浓度。根据CYP3A5或ATP结合饼干亚家族B会员1（ABCB1），性别和年龄的遗传变异来分析C / D值。 CYP3A5 * 3 / * 3组中的C / D值显着高于CYP3A5 * 1 / * 1和* 1 / * 3组（P <0.05，效果大小：D = 1.40）。在CYP3A5 * 3 / * 3组中，男性的Tacrolimus的浓度明显高于女性（P <0.05，效果大小：D = 1.78）。此外，在CYP3A5 * 3 / * 3组中，50多年龄比50岁以下女性的女性的Tacrolimus的浓度显着高（P <0.05，效果大小：D = 1.18）。相比之下，ABCB1遗传变异没有显示对C / D值的任何显着影响。由于CYP3A5 * 3 / * 3患者的躯干血症的血液浓度根据性和年龄而变化，因此在研究CYP3A中性别差异时应考虑这些因素。

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  • 来源
    《Biochemical Genetics》 |2017年第3期|共10页
  • 作者

    Ito Ayano; Okada Yuko; Hashita Tadahiro; Aomori Tohru; Hiromura Keiju; Nojima Yoshihisa; Nakamura Tomonori; Araki Takuya; Yamamoto Koujirou;

  • 作者单位

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

    Takasaki Univ Hlth &

    Welf Fac Pharm 60 Ohrui Machi Takasaki Gunma 3700033 Japan;

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Dept Med &

    Clin Sci Grad Sch Med 3-39-22 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Dept Med &

    Clin Sci Grad Sch Med 3-39-22 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

    Gunma Univ Hosp Dept Pharm 3-39-15 Showa Machi Maebashi Gunma 3718511 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    Tacrolimus; Sex difference; CYP3A5; CYP3A4; ABCB1;

    机译：tacrolimus;性别差异;CYP3A5;CYP3A4;ABCB1;

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