...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemistry >Recombinant Monoclonal Antibodies for Rabies Post-exposure Prophylaxis
【24h】

Recombinant Monoclonal Antibodies for Rabies Post-exposure Prophylaxis

机译：重组单克隆抗体用于狂犬病暴露的预防

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rabies virus is a prototypical neurotropic virus that causes one of the most dangerous zoonotic diseases in humans. Humanized or fully human monoclonal antibodies (mAb) that neutralize rabies virus would be the basis for powerful post-exposure prophylaxis of rabies in humans, having several significant benefits in comparison with human or equine rabies polyclonal immunoglobulins. The most advanced antibodies should broadly neutralize natural rabies virus isolates, bind with conserved antigenic determinants of the rabies virus glycoprotein, and show high neutralizing potency in assays in vivo. The antibodies should recognize nonoverlapping epitopes if they are used in combination. This review focuses on basic requirements for anti-rabies therapeutic antibodies. The urgency in the search for novel rabies post-exposure prophylaxis and methods of development of anti-rabies human mAb cocktail are discussed. The rabies virus structure and pathways of its penetration into the nervous system are also briefly described.
机译：狂犬病病毒是一种原型神经侵蚀病毒，导致人类中最危险的人畜共患病毒。中和狂犬病病毒的人源化或全锰单克隆抗体（MAB）是对人类狂犬病的强大曝光后预防的基础，与人或马兔多克隆免疫球蛋白相比具有几种显着益处。最先进的抗体应广泛中和天然狂犬病病毒分离物，与狂犬病病毒糖蛋白的保守抗原决定簇结合，并在体内测定中显示出高中和效力。如果组合使用，抗体应识别出非诱导表位。本综述重点介绍抗狂犬病治疗抗体的基本要求。讨论了寻找新型狂犬病的急性接触后预防和抗狂犬病人体MAB鸡尾酒的发育方法。还简要描述了狂犬病病毒结构和渗透到神经系统的途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号