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首页> 外文期刊>Cytokine >Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals.
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Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals.

机译：在HIV合并感染的个体中，慢性与隐性乙型肝炎病毒感染期间细胞因子的表达。

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Chronic hepatitis B virus infection is characterized by persistent detectable levels of hepatitis B surface antigen (HBsAg) and HBV DNA in the serum. In contrast, HBsAg is not detectable during occult HBV infection, despite the presence of HBV DNA. An altered host immune response could play a role in the development of occult HBV infection; however, potential differences in immune responses among chronic and occult HBV-infected patients have not been evaluated in vivo. In the current study, we evaluated serum levels of regulatory, apoptotic, and fibrotic/anti-fibrotic cytokines/markers as indicators of immune responses in 25 chronic and 12 occult HBV-infected patients. More than half of the patients in both chronic and occult HBV infection groups had IL-2, IL-4, IL-13, and IFN-gamma levels below detectable limits. In contrast, most patients had detectable levels of IL-8, IL-10, IP-10, sFas, sFasL, and TGF-beta1. Of these, only sFas was significantly different between the two groups, with lower levels observed during occult compared to chronic HBV infection (p=0.01). As a surrogate marker of apoptotic inhibition, decreased sFas during occult HBV infection suggests that apoptosis occurs at different rates in occult compared to chronic HBV infection and therefore, may contribute to persistence of occult HBV infection.
机译：慢性乙型肝炎病毒感染的特征是血清中的乙型肝炎表面抗原（HBsAg）和HBV DNA持续可检测水平。相反，尽管存在HBV DNA，在隐匿性HBV感染期间仍无法检测到HBsAg。宿主免疫应答的改变可能在隐匿性HBV感染的发生中起作用。但是，尚未在体内评估慢性和隐匿性HBV感染患者免疫应答的潜在差异。在当前的研究中，我们评估了血清中调节性，凋亡性和纤维化/抗纤维化细胞因子/标记物的水平，作为25位慢性和12位隐匿性HBV感染患者免疫应答的指标。慢性和隐匿性HBV感染组中一半以上的患者IL-2，IL-4，IL-13和IFN-γ水平低于可检测限。相比之下，大多数患者的IL-8，IL-10，IP-10，sFas，sFasL和TGF-beta1的水平均可检测到。其中，只有sFas在两组之间存在显着差异，与慢性HBV感染相比，潜伏期观察到的水平较低（p = 0.01）。作为凋亡抑制的替代标志物，隐匿性HBV感染期间sFas降低表明与慢性HBV感染相比，隐匿性细胞凋亡发生的速率不同，因此可能有助于隐匿性HBV感染的持续存在。

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