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首页> 外文期刊>Cytokine >Factors associated with inflammation markers, a cross-sectional analysis.
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Factors associated with inflammation markers, a cross-sectional analysis.

机译：与炎症标志物有关的因素，进行横断面分析。

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Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFalpha), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFalpha, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1beta, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.
机译：流行病学研究报告了循环炎症标志物与慢性疾病风险之间的关联。检验这些疾病的危险因素是否与炎症有关是令人感兴趣的。我们进行了一项横断面分析，以评估生殖和生活方式因素以及循环中的维生素D是否与炎症标志物相关，包括C反应蛋白，细胞因子（IL-1beta，IL-2，IL-4，IL-5，IL- 6，IL-10，IL-12p40，IL-12p70，IL-13，TNFalpha）和细胞因子调节剂（IL-1RA，sIL-1RII，sIL-2Ra，sIL-4R，sIL-6R，sTNF-R1 / R2 ），包括616名健康女性。我们证实了几种炎症标志物与年龄和BMI的关联。我们还观察到绝经后妇女与绝经前妇女（TNFalpha，sIL-1RII，sIL-2Ra）的某些炎症标记物水平显着升高，且胎次增加（IL-12p40），循环中的25（OH）维生素D含量较高（IL- 13），以及目前吸烟的非类固醇抗炎药（NSAIDs）（IL-1beta，IL-2，IL-10，IL-12p70和IL-12p40）和较低水平的吸烟者（IL-4，IL -13，IL-12p40）和有乳腺癌或卵巢癌家族史的妇女（IL-4，IL-10，IL-13）。我们的发现表明，慢性疾病的危险因素（年龄，BMI，更年期状态，均等，使用NSAID，乳腺癌和卵巢癌的家族病史以及吸烟）与健康女性的炎症标志物有关。

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