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Association of CTLA-4 and TNF-α polymorphism with recurrent miscarriage among North Indian women

机译：CTLA-4和TNF-α多态性与北印度女性反复流产的关系

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Context: CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT). n alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in placentas of abortion prone pregnancies. Objectives: The present study investigated the role of CTLA-4. +49 A/G, CTLA-4 (AT). n 3'UTR, TNF-α-308G/A and TNF-α-238G/A polymorphisms as a susceptibility marker for recurrent miscarriage (RM). Participants and methods: We genotyped CTLA4. +49A/G, TNF-α-308 and TNF-α-238 gene polymorphisms in 300 patients with RM and 500 age and ethnically matched negative controls using PCR-RFLP method. While gene sequencing method was adopted for studying the CTLA-4 (AT). n 3'UTR polymorphism. Results: The mutant homozygous genotype GG of CTLA4. +49A/G, AA genotype and A allele of TNF-α-308, G allele of TNF-α-238 were observed to be predisposing among RM cases along with the 104. bp, 106. bp, 110. bp and 116. bp alleles of CTLA-4 (AT). n microsatellite repeat. GA and AG haplotypes of TNF-α were low risk associated haplotypes among recurrent miscarriage women. Conclusions: Roles of CTLA-4 A49G, CTLA-4 (AT). n 3'UTR, TNF-α-308 and TNF-α-238 polymorphisms in RM cases from North India is reflected through this study.
机译：背景：CTLA-4参与效应细胞，这些细胞可能会改变信号转导，进而改变细胞因子的产生。 （AT）的更长重复序列的传输。 n CTLA-4等位基因也与反复流产的妇女有关。据报道，在容易流产的孕妇胎盘中，被称为胚胎毒性细胞因子的TNF-α含量更高。目的：本研究调查了CTLA-4的作用。 +49 A / G，CTLA-4（AT）。 n 3'UTR，TNF-α-308G/ A和TNF-α-238G/ A多态性是反复流产（RM）的易感性标记。参与者和方法：我们对CTLA4进行了基因分型。使用PCR-RFLP方法对300例RM和500岁患者以及种族匹配的阴性对照中的+ 49A / G，TNF-α-308和TNF-α-238基因多态性。同时采用基因测序方法研究CTLA-4（AT）。 n 3'UTR多态性。结果：CTLA4的突变纯合基因型GG。在RM病例中，观察到+ 49A / G，AA基因型和TNF-α-308的A等位基因，TNF-α-238的G等位基因与104. bp，106。bp，110。bp和116一起易患。 CTLA-4（AT）的bp等位基因。 n微卫星重复。在反复流产的女性中，TNF-α的GA和AG单倍型是低风险相关的单倍型。结论：CTLA-4 A49G，CTLA-4（AT）的作用。该研究反映了印度北部RM病例中n'3'UTR，TNF-α-308和TNF-α-238的多态性。

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