Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

SaumellS.; FlorensaL.; Lu?oE.; SanzoC.; Ca?izoC.; HernándezJ.M.; CerveraJ.; GallartM.A.; CarbonellF.; ColladoR.; ArenillasL.; PedroC.; BargayJ.; NomdedeuB.; XicoyB.; VallespíT.; RayaJ.M.; BellochL.; SanzG.F.; SoléF.

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Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

机译：三元素8作为一种异常异常的预后价值及额外细胞遗传学畸变对原发性髓细胞增强症的影响

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Trisomy 8 is the most common chromosomal gain in myelodysplastic syndromes (MDS), however, little is known about the features of MDS with isolated trisomy 8 and the influence of additional cytogenetic aberrations. We determined the characteristics and prognostic factors of 72 patients with trisomy 8 as a single anomaly and analysed also the impact of other aberrations added to trisomy 8 in another 62 patients. According to our study, MDS with isolated trisomy 8 was more frequent in men, with more than one cytopenia in most patients (62%) and having about 4% bone marrow blasts. The multivariate analysis demonstrated that platelet count and percentage bone marrow blasts had the strongest impact on overall survival (OS). The median OS for isolated trisomy 8, trisomy 8 plus one aberration (tr8 + 1), plus two (tr8 + 2) and plus three or more aberrations (tr8 + ≥3) was 34·3, 40, 23·4 and 5·8 months, respectively (P < 0·001). Trisomy 8 confers a poorer prognosis than a normal karyotype in MDS patients with ≥5% bone marrow blasts. This study supports the view that MDS with isolated trisomy 8 should be included in the intermediate cytogenetic risk group.

机译：Trisomy 8是Myelodysplastic综合征（MDS）中最常见的染色体增益，但是关于MDS的特征与分离的三元体8的特征很少，以及额外的细胞遗传学畸变的影响。我们确定了72例三元素8患者作为单一异常的特点和预后因素，并分析了另外62例患者在三兆癣中的影响。根据我们的研究，MDS与孤立的三术8中的MDS在男性中更频繁，大多数患者（62％）和大约4％的骨髓爆炸中有多于一种细胞脑。多变量分析表明，血小板计数和骨髓爆炸百分比对整体存活率的最强烈影响（OS）。用于隔离三元素8的中位操作系统，三元8加上一个像差（TR8 + 1），加上两个（TR8 + 2）和加三个或更多像差（TR8 +≥3）为34·3,40,23·4和5 ·分别为8个月（P <0·001）。三元8赋予较差的预后，而不是MDS患者≥5％骨髓爆炸的正常核型。本研究支持与孤立的三元素8的MDS应包括在中间细胞遗传学风险组中的视图。

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来源
《British Journal of Haematology》 |2012年第3期|共11页
作者
SaumellS.; FlorensaL.; Lu?oE.; SanzoC.; Ca?izoC.; HernándezJ.M.; CerveraJ.; GallartM.A.; CarbonellF.; ColladoR.; ArenillasL.; PedroC.; BargayJ.; NomdedeuB.; XicoyB.; VallespíT.; RayaJ.M.; BellochL.; SanzG.F.; SoléF.;
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Laboratori de Citologia Hematològica Laboratori de Citogenètica Molecular Serveis de Patologia i;

Laboratori de Citologia Hematològica Laboratori de Citogenètica Molecular Serveis de Patologia i;

Servicio de Hematología Hospital Universitario Central de Asturias Oviedo Spain;

Servicio de Hematología Hospital Universitario Central de Asturias Oviedo Spain;

Servicio de Hematología Hospital Universitario de Salamanca Salamanca Spain;

Servicio de Hematología Hospital Universitario de Salamanca Salamanca Spain;

Servicio de Hematología Hospital Universitario La Fe Valencia Spain;

Servei d'Hematología Hospital Universitari Arnau de Vilanova Lleida Spain;

Servicio de Hematología Hospital General de Valencia Valencia Spain;

Servicio de Hematología Hospital General de Valencia Valencia Spain;

Laboratori de Citologia Hematològica Laboratori de Citogenètica Molecular Serveis de Patologia i;

Laboratori de Citologia Hematològica Laboratori de Citogenètica Molecular Serveis de Patologia i;

Servicio de Hematología Hospital Son Llàtzer Mallorca Spain;

Servei d'Hematología Hospital Clínic Barcelona Barcelona Spain;

Servei d'Hematología Hospital Universitari Germans Trias i Pujol Badalona Spain;

Servei d'Hematología Hospital Vall d'Hebron Barcelona Spain;

Servicio de Hematología Hospital Universitario de Canarias La Laguna-Tenerife Spain;

Servicio de Hematología Hospital Universitario La Fe Valencia Spain;

Servicio de Hematología Hospital Universitario La Fe Valencia Spain;

Laboratori de Citologia Hematològica Laboratori de Citogenètica Molecular Serveis de Patologia i;

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正文语种 eng
中图分类血液及淋巴系疾病;
关键词
Cytogenetic aberrations; Myelodysplastic syndromes; Trisomy 8;

机译：细胞遗传学畸变;骨髓增生症综合征;三重子8;

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1. Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes [J] . SaumellS., FlorensaL., Lu?oE., British Journal of Haematology . 2012,第3期

机译：三体性8作为单一异常的预后价值以及其他细胞遗传异常在原发性骨髓增生异常综合症中的影响
2. Clinical Prognostic Factors in 86 Chinese Patients with Primary Myelodysplastic Syndromes and Trisomy 8: A Single Institution Experience [J] . Yue Qing-Fang, Chen Lei, She Xiao-Mei, Yonsei Medical Journal . 2016,第2期

机译：86例中国原发性增生异常综合征和三体综合征8患者的临床预后因素：单一机构经验
3. Impacts of cytogenetic categories in the Revised International Prognostic Scoring System on the prognosis of primary myelodysplastic syndromes: Results of a single-center study [J] . QuS., XuZ., ZhangY., Leukemia and lymphoma . 2012,第5期

机译：经修订的国际预后评分系统中细胞遗传学类别对原发性骨髓增生异常综合症预后的影响：单中心研究结果
4. Ras gene mutation in acute myeloid leukemia and Myelodysplastic syndromes: a meta-analysis of its occurrence and prognostic relevance [C] . Cheng Jingru, Wang Peng, Zhang Tai, International Conference on Advanced Materials and Computer Science . 2016

机译：RAS基因突变在急性髓性白血病和髓细胞增强综合征中：荟萃分析其发生和预后相关性
5. CD16xCD33 bispecific killer cell engager (BiKE) activates natural killer (NK) cells from myelodysplastic syndrome (MDS) patients against primary MDS and myeloidderived suppressor cell (MDSC) CD33-positive targets. [D] . Gleason, Michelle K. 2014

机译：CD16xCD33双特异性杀伤细胞接合剂（BiKE）激活来自骨髓增生异常综合征（MDS）患者的自然杀伤（NK）细胞，以抵抗原发性MDS和髓样抑制细胞（MDSC）CD33阳性靶标。
6. High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Behçets Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Behçets Disease Database and Comparison with the Literature [O] . Yan Shen, Hai-Fen Ma, Dan Luo, -1

机译：八三体的胃肠道溃疡和细胞遗传学异常高发是贝切特病与骨髓增生异常综合症相关的典型特征：来自上海贝切特病数据库的16例连续中国患者及其文献比较
7. Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes [O] . Saumell Tutusaus Silvia, Florensa Brichs Lourdes, Luño Fernández Elisa, 2012

机译：三体性8作为单一异常的预后价值以及其他细胞遗传异常在原发性骨髓增生异常综合症中的影响

Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

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