• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British journal of ophthalmology >Preservatives in glaucomamedication
【24h】

Preservatives in glaucomamedication

机译：青光眼药物的防腐剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Preservatives continue to be in widespread use in ophthalmic medications due to the convenience they provide, regulatory requirements and the higher cost of alternatives. Benzalkonium chloride (BAK) remains the most commonly used preservative but there is a trend towards the use of preservative-free (PF)drops for glaucoma, although at a higher price. An extensive body of literature explores BAK toxicity on ocular structures in animal and laboratory studies (in vitro and in vivo). Non-randomised controlled studies have provided some supporting evidence of its toxicity in patients, especially in those with pre-existing ocular surface disease (OSD) or on multiple medications. However, there have been very few randomised controlled trials that compare the same medication with and without BAK preservative. Several of these trials have never been published in any peer reviewed journals. Notwithstanding, those that have been published, have not demonstrated any clear benefits of the BAK-free formulations. Short duration and exclusion of those with OSD are limitations of these studies. There is a lack of evidence of clinically significant harm from a small number of BAK preserved drops in patients without OSD. This means that generally more expensive PF glaucoma medications should only be recommended for those on poly pharmacy or those with OSD but are not necessarily required for all patients.
机译：由于他们提供的便利性，监管要求和更高的替代成本，防腐剂在眼科药物中继续普遍使用。苯扎数氯化物（Bak）仍然是最常用的防腐剂，但虽然以更高的价格，使用无金属状的防腐剂（PF）滴剂存在趋势。一系列广泛的文献探讨了动物和实验室研究中眼结构的Bak毒性（体外和体内）。非随机对照研究已经提供了一些支持患者毒性的证据，特别是在具有预先存在的眼部疾病（OSD）或多种药物上的患者中的毒性。然而，已经有很少的随机对照试验，可比较相同的药物和没有Bak防腐剂的药物。这些试验中的一些从未在任何同行评审期刊上发表过。尽管如此，已发布的那些，但没有表现出无巴旁制剂的任何明显的益处。持续时间和排除具有OSD的持续时间和排除是这些研究的局限性。没有OSD的患者少数Bak保存液滴缺乏临床危害的证据。这意味着只有普遍昂贵的PF青光眼药物应仅推荐用于聚合物药房或具有OSD的那些，但不一定是所有患者所必需的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号