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首页> 外文期刊>Cytokine >Body fat distribution has no effect on serum visfatin levels in healthy female subjects.
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Body fat distribution has no effect on serum visfatin levels in healthy female subjects.

机译：身体脂肪分布对健康女性受试者的血清visfatin水平没有影响。

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摘要

Obesity is the presence of either abnormal absolute amount or relative proportion of body fat. Contrary to gluteal obesity, visceral obesity is associated with different metabolic alterations including insulin resistance (IR). A relatively new adipocytokine visfatin is shown to be expressed predominantly in visceral fat and exhibit insulin-mimicking effects in rodents. It is still unclear whether serum visfatin levels are associated with increased total or visceral fat mass in humans. The aim of our study was to investigate the relation between visfatin and obesity parameters namely body mass index (BMI) and waist circumference (WaC) and IR in healthy female subjects. Eighty one female subjects 20 years of age, having no diagnosis of glucose intolerance or diabetes, hypertension and dyslipidemia were chosen. The patients were divided into four groups according to their BMI and WaC values. Serum visfatin and HOMA-IR levels did not differ among groups. No correlation was detected between serum visfatin levels and obesity and metabolic parameters. In conclusion, we demonstrated that body fat distribution did not affect serum visfatin levels in healthy female subjects. Further studies are needed to clarify the exact factors influencing and determining serum visfatin levels and its clinical reflections.
机译：肥胖是指身体脂肪的绝对绝对含量或相对比例存在。与臀型肥胖相反，内脏型肥胖与包括胰岛素抵抗（IR）在内的不同代谢改变有关。相对较新的脂肪细胞因子visfatin已显示主要在内脏脂肪中表达，并在啮齿动物中表现出模仿胰岛素的作用。尚不清楚血清visfatin水平是否与人体总脂肪或内脏脂肪量增加有关。我们研究的目的是研究健康女性受试者中visfatin与肥胖参数之间的关系，即体重指数（BMI）和腰围（WaC）和IR。选择二十一名未诊断为葡萄糖耐量异常或糖尿病，高血压和血脂异常的女性受试者，年龄为20岁。根据患者的BMI和WaC值将其分为四组。两组之间的血清visfatin和HOMA-IR水平没有差异。在血清visfatin水平与肥胖和代谢参数之间未发现相关性。总之，我们证明了健康女性受试者的体内脂肪分布不会影响血清visfatin水平。需要进一步的研究来阐明影响和确定血清visfatin水平的确切因素及其临床反映。

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