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首页> 外文期刊>Cell motility and the cytoskeleton >Actin isoform expression patterns during mammalian development and in pathology: insights from mouse models.
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Actin isoform expression patterns during mammalian development and in pathology: insights from mouse models.

机译：哺乳动物发展和病理学期间的肌动蛋白同种型表达模式：小鼠模型的见解。

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摘要

The dynamic actin cytoskeleton, consisting of six actin isoforms in mammals and a variety of actin binding proteins is essential for all developmental processes and for the viability of the adult organism. Actin isoform specific functions have been proposed for muscle contraction, cell migration, endo- and exocytosis and maintaining cell shape. However, these specific functions for each of the actin isoforms during development are not well understood. Based on transgenic mouse models, we will discuss the expression patterns of the six conventional actin isoforms in mammals during development and adult life. Ablation of actin genes usually leads to lethality and affects expression of other actin isoforms at the cell or tissue level. A good knowledge of their expression and functions will contribute to fully understand severe phenotypes or diseases caused by mutations in actin isoforms.
机译：由哺乳动物中的六种肌动蛋白同种型组成的动态肌动蛋白细胞骨架和各种肌动蛋白结合蛋白是所有发育过程和成人生物的可行性必不可少。 已经提出了肌动蛋白同种型特定功能，用于肌肉收缩，细胞迁移，内毒性和远足尿症和维持细胞形状。 然而，在发育过程中每种肌动蛋白同种型的这些特定功能尚不清楚。 基于转基因小鼠模型，我们将在开发和成年生命期间讨论哺乳动物中六种常规肌动蛋白同种型的表达模式。 杀灭肌动蛋白基因通常导致致死态，并影响在细胞或组织水平的其他肌动蛋白同种型的表达。 对其表达和功能的良好了解将有助于充分了解由肌动蛋白同种型突变引起的严重表型或疾病。

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