...
首页> 外文期刊>Cellular immunology >A proliferation-inducing ligand (APRIL) induced hyper-production of IgA from tonsillar mononuclear cells in patients with IgA nephropathy
【24h】

A proliferation-inducing ligand (APRIL) induced hyper-production of IgA from tonsillar mononuclear cells in patients with IgA nephropathy

机译:诱导诱导IgA肾病患者扁桃体单核细胞的IgA的增殖配体(4月)

获取原文
获取原文并翻译 | 示例
           

摘要

IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing ligand (APRIL), homologous to BAFF. IgAN-TMCs produced more APRIL than non IgAN-TMCs in the presence of both CpG-ODN and control-ODN. TLR9 expression was higher in B-cells of IgAN-TMCs, and treatment with CpG-ODN enhanced transmembrane activator and CAML interactor (TACI) expression. IgA production from IgAN-TMCs was inhibited by APRIL neutralization antibody or TACI blocking antibody, and enhanced by co-treatment of APRIL and CpG-ODN. Serum APRIL levels were higher in patients with IgAN, and decreased after tonsillectomy. These findings suggest that APRIL is involved in the hyperproduction of IgA from IgAN-TMCs, and that CpG-ODN enhanced APRIL-induced IgA production by increasing TACI expression on B-cells of IgAN-TMCs.
机译:IgA肾病(Igan)是一种与扁桃体相关的疾病。我们以前表明,寡脱氧核苷酸与CpG(CPG-ODN)和B细胞活化因子(BAFF)涉及来自IGAN(IGAN-TMCs)的扁桃体单核细胞的IgA的Suploduction。在这项研究中,我们专注于诱导的增殖配体(四月),对BAFF同源。在CPG-ODN和CONTOR-ODN的情况下,IGAN-TMCs在存在时比非IGAN-TMC产生更多的4月。 IGAN-TMCs的B细胞中TLR9表达较高,并用CPG-ODN增强跨膜激活剂和CAML交流剂(TACI)表达处理。来自4月份中和抗体或菌落阻断抗体的IgA产生的IgA生产,并通过4月和CpG-ODN的共同治疗增强。 Igan患者血清4月份水平较高,并在扁桃体切除术后降低。这些发现表明,4月份参与IGAN-TMC的IGA的大实生产,并且CPG-ODN通过增加IgAn-TMCs的B细胞的TACI表达来增强4月诱导的IgA产生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号