...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical autonomic research: Official journal of the Clinical Autonomic Research Society >Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms
【24h】

Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms

机译：慢性阻塞性肺疾病心率变异性的复杂性分析：严重程度与症状的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose Chronic obstructive pulmonary disease (COPD) negatively impacts autonomic control of the heart rate, as assessed by time and frequency domains of heart rate variability (HRV) analysis. However, it is unknown whether symbolic dynamic analysis may identify cardiac autonomic impairment, and whether such nonlinear indices may be associated with disease severity, prognostic markers, perceived dyspnea and functional capacity in patients with COPD. The current study assessed cardiac autonomic modulation by symbolic analysis of HRV in patients with COPD compared with healthy controls. Methods We recruited 54 COPD patients and 20 healthy controls. The interval between two successive R-wave peaks was calculated in the resting supine position. HRV was analyzed using symbolic markers and Shannon entropy (SE). The six-minute walk test (6MWT) was applied in a 30-m corridor. Results We found a lower 6MWT distance in patients with COPD compared with healthy controls (p < 0.05). We found increased SE and decreased percentage of no variation patterns (0V%) in COPD patients compared with the control group (p = 0.001). Significant correlations were found between the percentage of one variation pattern (1V%) and the Medical Research Council dyspnea scale (r = 0.38, p = 0.01), BODE index (r = 0.38, p = 0.01), forced expiratory volume in the first second (FEV1) [L] (r = -0.44, p = 0.003) and FEV1 [%] (r = -0.35, p = 0.02). It was found that SE was inversely associated with 0V% (r = -0.87, p < 0.0001). Conclusion COPD patients present with depressed sympathetic modulation of HR and higher SE compared with healthy controls. This increased irregularity was inversely associated with 0V%. These results suggested that COPD patients seem to have a cardiac control shifted towards a parasympathetic predominance compared with controls. Symbolic dynamic and complexity index of HRV are related to disease severity, symptoms and functional impairment in these patients.
机译：目的慢性阻塞性肺疾病（COPD）对心率的自主控制产生负面影响，如心率变异性（HRV）分析的时间和频率域评估。然而，尚不清楚符号动态分析是否可以识别心脏自主损伤，以及这种非线性指数是否可能与COPD患者的疾病严重程度，预后标志物，感知呼吸困难和功能能力相关。目前研究评估了与健康对照相比COPD患者HRV象征性分析的心脏自主调制。方法招聘了54名COPD患者和20例健康对照。在静止仰卧位置计算两个连续的R波峰之间的间隔。使用符号标记和香农熵（SE）分析HRV。六分钟的步行测试（6MWT）应用于30米的走廊。结果我们发现COPD患者的6MWT距离与健康对照相比（P <0.05）。与对照组相比，我们发现COPD患者中没有变异模式（0V％）的增加和下降百分比（P = 0.001）。在一个变异模式（1V％）和医学研究委员会呼吸困难（R = 0.38，P = 0.01）的百分比之间发现了显着的相关性（r = 0.38，p = 0.01），首先强制呼气量第二（FEV1）[L]（r = -0.44，p = 0.003）和fev1 [％]（r = -0.35，p = 0.02）。发现SE与0V％（r = -0.87，p <0.0001）相反。结论与健康对照相比，HR和较高SE的抑制交感神经调节患者表现出。这种增加的不规则性与0V％相反。这些结果表明，与对照组相比，COPD患者似乎具有朝向副交感神经统治的心脏控制。 HRV的象征性动态和复杂性指数与这些患者的疾病严重程度，症状和功能障碍有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号