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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Serum neopterin for early assessment of severity of severe acute respiratory syndrome.
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Serum neopterin for early assessment of severity of severe acute respiratory syndrome.

机译：血清Neopterin，用于早期评估严重急性呼吸综合征的严重程度。

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Neopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and rose to a maximum level of 45.0 nmol/L 3 days after the onset. All SARS patients had elevated neopterin concentrations (>10 nmol/L) within 9 days after the onset. The mean neopterin concentrations were 34.2 nmol/L in acute sera of SARS patients, 5.1 nmol/L in convalescent sera, and 6.7 nmol/L in healthy controls. In contrast, the mean CRP concentrations in both acute and convalescent sera of SARS patients were in the normal range (<10 mg/L). Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease, while there was no significant correlation between the CRP level and the fever period. Serum neopterin may allow early assessment of the severity of SARS. The decrease of neopterin level was found after steroid treatment, which indicates that blood samples should be collected before steroid treatment for the neopterin measurement.
机译：在129名重型急性呼吸综合征（SARS）患者和156名健康献血者中，在血清样品中测定Neopterin和C反应蛋白（CRP）浓度。在确诊的SARS患者中，已经在症状发作的日期进行了早期的Neopterin升级，并在发作后3天升至最高水平的45.0 Nmol / L.所有SARS患者在发病后9天内均升高了Neopterin浓度（> 10 Nmol / L）。平均Neopterin浓度为34.2米氧化Nmol / L在SARS患者的急性血清中，5.1nmol / L在康复血清中，6.7 nmol / L健康对照。相反，SARS患者急性和临床血清中的平均CRP浓度在正常范围内（<10mg / L）。 SARS患者的血清Neopterin水平与发热期有关，因此疾病的临床进展，而CRP水平与发烧期无明显相关性。血清Neopterin可以早期评估SARS的严重程度。在类固醇治疗后发现新型水平的降低，这表明应在服饰治疗前收集血液样品进行Neopterin测量。

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