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首页> 外文期刊>Abdominal radiology. >Gadoxetic acid enhanced magnetic resonance imaging for prediction of the postoperative prognosis of intrahepatic mass-forming cholangiocarcinoma
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Gadoxetic acid enhanced magnetic resonance imaging for prediction of the postoperative prognosis of intrahepatic mass-forming cholangiocarcinoma

机译：乙酰基酸增强磁共振成像，用于预测肝内成分胆管癌术后预后

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Purpose: To identify imaging markers that independently predict the post-operative outcome of intrahepatic mass-forming cholangiocarcinoma (IMCC) using gadoxetate disodium-enhanced magnetic resonance imaging (MRI). Methods: Data from 54 patients who underwent pre-operative gadoxetate disodium-enhanced MRI and curative surgery for IMCC were retrospectively evaluated. The prognostic power of various imaging and pathological features reportedly associated with recurrence-free survival (RFS) and overall survival (OS) was analyzed using Cox regression models. A model combining imaging and pathological features was developed and its performance was evaluated using the Harrell C-index and Akaike information criterion. Results: Capsule penetration (P = 0.016) and tumor size (P = 0.015) were independent markers for worse RFS, while capsule penetration (P = 0.012) and hepatic vein obstruction (HVO, P = 0.016) were independent markers for worse OS, respectively, in the imaging-based model. Capsule penetration was the only imaging marker identified in the combined prediction model of RFS, and the combined model showed a higher C-index and lower AIC value compared with the model based on pathological features alone. Conclusions: Capsule penetration and HVO on MRI are significantly worse imaging prognostic factors for postoperative outcomes in patients with IMCC. Incorporation of capsule penetration and HVO into a surgical staging system may improve prediction of the post-operative prognosis of IMCC.
机译：目的：鉴定使用乙酸酯二钠增强的磁共振成像（MRI）独立地预测肝内成分胆管癌（IMCC）后术后结果的成像标记。方法：回顾性评估了来自54例接受术前乙二醇酯二钠增强MRI和治疗方法的54例患者的数据。使用COX回归模型分析了与无复发存活（RFS）和总存活（OS）分析了各种成像和病理特征的预后功率。开发了一种组合成像和病理特征的模型，并使用Harrell C-Index和Akaike信息标准评估其性能。结果：胶囊渗透（P = 0.016）和肿瘤大小（P = 0.015）是较差的RFS的独立标志物，而胶囊渗透（P = 0.012）和肝静脉阻塞（HVO，P = 0.016）是较差的OS的独立标记，分别在基于成像的模型中。胶囊渗透是RFS的组合预测模型中唯一鉴定的唯一成像标记，而组合模型与单独的病理特征的模型相比，较高的C折射率和降低的AIC值。结论：胶囊渗透和HVO对IMCC患者术后术后的成像预后因素显着较差。将胶囊渗透和HVO掺入手术分期系统可以改善IMCC后术后预后的预测。

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