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首页> 外文期刊>Acta biomaterialia >The inflation response of the human lamina cribrosa and sclera: Analysis of deformation and interaction
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The inflation response of the human lamina cribrosa and sclera: Analysis of deformation and interaction

机译：人椎板克里泽和巩膜的通胀反应：变形和相互作用分析

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This study investigated the inflation response of the lamina cribrosa (LC) and adjacent peripapillary sclera (PPS) in post-mortem human eyes with no history of glaucoma. The posterior sclera of 13 human eyes from 7 donors was subjected to controlled pressurization between 5-45 mmHg. A laser-scanning microscope (LSM) was used to image the second harmonic generation (SHG) response of collagen and the two-photon fluorescent (TPF) response of elastin within the volume of the LC and PPS at each pressure. Image volumes were analyzed using digital volume correlation (DVC) to calculate the three-dimensional (3D) deformation field between pressures. The LC exhibited larger radial strain, E-rr, and maximum principal strain, E-max, (p < 0.0001) and greater posterior displacement (p = 0.0007) compared to the PPS between 5-45 mmHg, but had similar average circumferential strain, E-theta theta, and maximum shear strain, Gamma(max). The E-max and Gamma(max) were highest near the LC-PPS interface and lowest in the nasal quadrant of both tissues. Larger LC area was associated with smaller E-max in the peripheral LC and larger E-max in the central LC (p <= 0.01). The E-max, Gamma(max), and E-theta theta in the inner PPS increased with increasing strain in adjacent LC regions (p <= 0.001). Smaller strains in the PPS were associated with a larger difference in the posterior displacement between the PPS and central LC (p < 0.0001 for E-max and E-rr), indicating that a stiffer pressure-strain response of the PPS is associated with greater posterior bowing of the LC.
机译：本研究调查了杀死人眼中椎板克里泽（LC）和相邻的植物眼睛（PPS）的膨胀反应，其验尸的人眼没有青光眼的历史。从7个供体的13个人眼后的后巩膜受到5-45mmHg的受控加压。激光扫描显微镜（LSM）用于在每次压力下对LC和PPS的体积内的弹性蛋白的二次谐波产生（SHG）响应和弹性​​蛋白的两极荧光（TPF）响应。使用数字音量相关（DVC）分析图像卷来计算压力之间的三维（3D）变形场。与5-45mmHg之间的PPS相比，LC显示出较大的径向菌株，E-RR和最大主应变，E-MAX，（P <0.0001）和更高的后位移（P = 0.0007），但具有相似的平均周向应变，e-thetaθ和最大剪切应变，γ（max）。 e-max和γ（max）在LC-PPS接口附近最高，并且在两个组织的鼻象限中最低。较大的LC区域与周边LC中的较小的E-MAX相关联，中央LC中的较大E-MAX（P <= 0.01）。内部PPS中的E-MAX，γ（MAX）和E-THETA增加，相邻LC区域中的应变增加（P <= 0.001）。 PPS中的较小菌株与PPS和中央LC之间的后部位移的较大差异有关（用于E-MAX和E-RR的P <0.0001），表明PPS的静止压力应变响应与更大相关LC的后弓。

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