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首页> 外文期刊>Cytokine >Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity
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Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity

机译：短期运动训练在肥胖症中减少白细胞介素-10的抗炎作用

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摘要

A key pathological component of obesity is chronic low-grade inflammation, which is propagated by infiltration of immune cells into tissues and overproduction of pro-inflammatory cytokines. Cytokines that possess anti-inflammatory properties, such as interleukin (IL)-10 and IL6, may also play an important role. This study was designed to determine the impact of short-term exercise on the anti-inflammatory action of IL10 and IL6. Thirty-three inactive obese adults were randomized to two weeks of high-intensity interval training (HIIT) or moderate intensity continuous training (MICT). Fasting blood samples were collected before and after training. Lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha production was measured in whole blood cultures in the presence or absence of IL10 or IL6. IL10 and IL6 receptor expression were measured on circulating monocytes, neutrophils, and T cells. HIIT and MICT reduced the ability of IL10 to inhibit LPS-induced TNF alpha production, with a greater effect with HIIT (Group x Time and IL10 x Time interactions, p's 0.05). This reduction in 1110 function was not explained by altered IL10R1 expression, which was unchanged after training (p 0.05). HIIT and MICT differentially affected IL6 function (Group x Time and IL6 x Time interactions, p's 0.05) with evidence of reductions in the anti-inflammatory ability of IL6 with HIIT. Neither HIIT nor MICT altered levels of circulating IL10, IL6, or TNF alpha. The impact of short-term HIIT and MICT resulted in differential effects on anti-inflammatory cytokine function. The clinical implications remain to be determined but these novel findings indicate that measuring anti-inflammatory cytokine action could reveal important immunomodulatory effects of exercise.
机译：肥胖的关键病理成分是慢性低级炎症，其通过免疫细胞渗透到组织中和促炎细胞因子的过度生产中繁殖。具有抗炎性质的细胞因子，例如白细胞介素（IL）-10和IL6，也可能起到重要作用。本研究旨在确定短期运动对IL10和IL6抗炎作用的影响。三十三个无活性肥胖的成年人随机分为两周的高强度间隔训练（HIIT）或中等强度连续培训（MICT）。在训练之前和之后收集空腹血样。在存在或不存在IL10或IL6的情况下，在全血培养中测量脂多糖（LPS）诱导的肿瘤坏死因子（TNF）生产。在循环单核细胞，中性粒细胞和T细胞上测量IL10和IL6受体表达。 HIIT和MICT降低了IL10抑制LPS诱导的TNFα产生的能力，具有更大的效果，具有更大的效果（X时间和IL10 x时间相互作用，P's 0.05）。在训练后没有改变的IL10R1表达，未解释1110功能的这种减少，这在训练后没有变化（P＆GT; 0.05）。 HIIT和MICT差异影响的IL6功能（组X时间和IL6 X时间相互作用，P的＆ 0.05），具有抗炎症能力的抗炎能力与HIIT。既不是HEIT也不是MICT循环IL10，IL6或TNF alpha的水平。短期HIIT和MICT的影响导致抗炎细胞因子功能的差异影响。仍有待确定的临床意义，但这些新发现表明，测量抗炎细胞因子作用可以揭示运动的重要免疫调节作用。

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