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Injection drug use, food insecurity, and HIV-HCV co-infection: a longitudinal cohort analysis

机译：注射药物使用，食品不安全和HIV-HCV共感染：纵向队列分析

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摘要

Injection drug use (IDU) and food insecurity (FI) are highly prevalent among individuals living with HIV-hepatitis C virus (HCV) co-infection. We quantified the association between IDU and FI among co-infected individuals using biannual data from the Canadian Co-infection Cohort (N=608, 2012-2015). IDU (in the past six months) and IDU frequency (non-weekly/weekly in the past month) were self-reported. FI (in the past six months) and FI severity (marginal FI, moderate FI, and severe FI) were measured using the Household Food Security Survey Module. Generalized estimating equations were used to estimate risk ratios (RR) quantifying the associations between IDU, IDU frequency, and FI with Poisson regression. The associations between IDU, IDU frequency, and FI severity were quantified by relative-risk ratios (RRR) estimated with multinomial regression. At the first time-point in the analytical sample, 54% of participants experienced FI in the past six months, 31% engaged in IDU in the six months preceding the FI measure, and 24% injected drugs in the past month. After adjustment for confounding, IDU in the past six months (RR=1.15, 95% confidence interval [CI]=1.04-1.28) as well as non-weekly (RR=1.15, 95% CI=1.02-1.29) and weekly IDU (RR=1.21, 95% CI=1.07-1.37) in the past month are associated with FI. Weekly IDU in the past month is also strongly associated with severe FI (RRR=2.68, 95% CI=1.47-4.91). Our findings indicate that there is an association between IDU and FI, particularly weekly IDU and severe FI. This suggests that reductions in IDU may mitigate FI, especially severe FI, in this vulnerable subset of the HIV-positive population.
机译：注射药物使用（IDU）和食物不安全（FI）在患有HIV-丙型肝炎病毒（HCV）的个体中具有高度普遍的患有HIV-丙型肝炎病毒（HCV）的共感染。我们使用来自加拿大共感应队（N = 608,2012-2015）的两年数据来量化了IDU和FI之间的关联。 IDU（过去六个月）和IDU频率（过去一个月非每周/每周）都是自我报告的。使用家庭食品安全调查模块测量了FI（在过去六个月）和FI严重程度（边缘FI，中度，和严格的）。广义估计方程用于估计风险比（RR）量化IDU，IDU频率和FI与泊松回归之间的关联。通过多项式回归估计的相对风险比（RRR）来量化IDU，IDU频率和FI严重程度之间的关联。在分析样本的第一次点，54％的参与者在过去的六个月中经历过，31％在文件前六个月内从事IDU，并在过去一个月内注射了24％的药物。在调整混淆后，过去六个月的IDU（RR = 1.15,95％置信区间[CI] = 1.04-1.28）以及非每周（RR = 1.15,95％CI = 1.02-1.29）和每周IDU （RR = 1.21,95％CI = 1.07-1.37）与FI有关。过去一个月的每周IDU也与严重的FI（RRR = 2.68,95％CI = 1.47-4.91）密切相关。我们的调查结果表明，IDU和FI之间存在关联，特别是每周一次和严重的FI。这表明，在艾滋病毒阳性群体的这种脆弱的子集中，IDU的减少可能会降低FI，特别是严重的FI。

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  • 来源
    《AIDS care.》 |2018年第10期|共7页
  • 作者

    McLinden Taylor; Moodie Erica E. M.; Harper Sam; Hamelin Anne-Marie; Anema Aranka; Aibibula Wusiman; Klein Marina B.; Cox Joseph;

  • 作者单位

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

    Univ British Columbia Fac Land &

    Food Syst Vancouver BC Canada;

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

    McGill Univ Hlth Ctr Chron Viral Illness Serv Montreal PQ Canada;

    McGill Univ Dept Epidemiol Biostat &

    Occupat Hlth 1020 Pine Ave West Montreal PQ H3A 1A2 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    HIV; hepatitis C virus; injection drug use; food insecurity;

    机译：艾滋病毒;丙型肝炎病毒;注射药物使用;粮食不安全;

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