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首页> 外文期刊>AIDS Research and Human Retroviruses >Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Form in Guizhou, China
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Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Form in Guizhou, China

机译：贵州新型HIV-1 CRF01_AE / CRF07_BC重组病毒形式的表征

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摘要

We identified a novel CRF01_AE and 07_BC HIV-1 recombinant form in Guizhou province in southwest China. The phylogenetic analysis of the near full-length sequence reveals that it was divided into five segments by four breakpoints, and the CRF01_AE regions of the recombinant were clustered with subcluster 4 lineage of CRF01_AE, which mainly circulated among men who have sex with men (MSM) in China. The CRF07_BC regions of the recombinant were clustered with CRF07_BC lineage, which circulated among Chinese MSM. This is the first detection of a novel HIV-1 second-generation recombinant form (CRF07_BC/CRF01_AE) in Guizhou, which shows the increasing significance of heterosexual transmission contributing to the complexity of the HIV-1 epidemic in southwest China, and more effort measures should be taken to monitor the genetic evolution of HIV-1 strains and prevent HIV-1 transmissions.
机译：我们在中国西南部省省贵州省鉴定了一种新的CRF01_AE和07_BC HIV-1重组形式。 近全长序列的系统发育分析表明，通过四个断点分为五个段，重组的CRF01_AE区域与CRF01_AE的子簇4谱系聚集，这主要是与男性发生性关系的男性（MSM ） 在中国。 将重组的CRF07_BC区域与CRF07_BC谱系聚集，其在中文MSM中循环。 这是贵州新型HIV-1第二代重组形式（CRF07_BC / CRF01_AE）的首次检测，这表明异性恋传播越来越重要导致中国西南地区HIV-1流行病的复杂性以及更多的努力措施 应采取监测HIV-1菌株的遗传演进并防止HIV-1传输。

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  • 作者

    Wu Li; Huang Ling; Zhang Wangming; Liu Jinhe; Kong Yihua;

  • 作者单位

    Peoples Hosp Zunyi City Bo Zhou Dist Zunyi Peoples R China;

    Peoples Hosp Zunyi City Bo Zhou Dist Zunyi Peoples R China;

    Guiyang Univ Chinese Med Affiliated Hosp 1 Guiyang Guizhou Peoples R China;

    Guizhou Med Univ Tissue Engn &

    Stem Cell Res Ctr Guiyang Guizhou Peoples R China;

    Guizhou Med Univ Affiliated Hosp 2 Guiyang 556000 Guizhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    CRF01_AE/CRF07_BC; HIV; China;

    机译：CRF01_AE / CRF07_BC;艾滋病毒;中国;

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