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首页> 外文期刊>AIDS Research and Human Retroviruses >Identification of a Novel HIV-1 Unique Recombinant Form Between B, CRF01_AE and CRF07_BC in Men Who Have Sex with Men in Guangxi, China
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Identification of a Novel HIV-1 Unique Recombinant Form Between B, CRF01_AE and CRF07_BC in Men Who Have Sex with Men in Guangxi, China

机译：在中国广西男子与男性发生性关系的男性中鉴定B，CRF01_AE和CRF07_BC之间的新型HIV-1独特的重组形式

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摘要

B, CRF01_AE and CRF07_BC are three major HIV-1 subtypes circulating in China. Here we detected a novel CCR5-tropic HIV-1 recombinant virus (GX2016EU23), which was isolated from an HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of the near full-length genome showed that GX2016EU23 consisted of at least seven segments, that is two B, two CRF01_AE, and three CRF07_BC segments. Recombinant breakpoints of GX2016EU23 were observed in the gag , pol , rev , and env regions. This is the first detection of a novel HIV-1 recombinant (B/CRF01_AE/CRF07_BC) in MSM in Guangxi. The emergence of this novel recombinant suggests the increasing genetic diversity of the HIV-1 epidemic among the MSM group in China.
机译：B，CRF01_AE和CRF07_BC是中国循环的三个主要HIV-1亚型。 在这里，我们检测了一种新型CCR5-Tropic HIV-1重组病毒（GX2016EU23），其与中国广西广西男人（MSM）发生性关系的HIV-1感染者分离出来。 近全长基因组的系统发育分析显示，GX2016EU23由至少七个段组成，即两个B，两个CRF01_AE和三个CRF07_BC段。 在GAG，Pol，Rev和Evitions中观察到GX2016EU23的重组断点。 这是在广西MSM中的第一次检测MSM中的新型HIV-1重组（B / CRF01_AE / CRF07_BC）。 这种新型重组的出现表明了中国MSM集团HIV-1流行病的遗传多样性。

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  • 作者

    Kong Desheng; Wang Yan; Wang Chen; Liang Shujia; Feng Yi; Shao Yiming; Ma Liying;

  • 作者单位

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

    Guangxi Center for Disease Prevention and Control Nanning China.;

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

    State Key Laboratory of Infectious Disease Prevention and Control Division of Virology and;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    HIV-1; HIV-1 transmission; epidemiology;

    机译：HIV-1;HIV-1变速器;流行病学;

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