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首页> 外文期刊>Alcohol >A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice
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A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice

机译：单一的酒精饮用会议足以使小鼠随后的耐脂性消耗

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摘要

Addiction is mediated in large part by pathological motivation for rewarding, addictive substances, and alcohol-use disorders (AUDs) continue to extract a very high physical and economic toll on society. Compulsive alcohol drinking, where intake continues despite negative consequences, is considered a particular obstacle during treatment of AUDs. Aversion-resistant drives for alcohol have been modeled in rodents, where animals continue to consume even when alcohol is adulterated with the bitter tastant quinine, or is paired with another aversive consequence. Here, we describe a two-bottle choice paradigm where C57BL/6 mice first had 24-h access to 15% alcohol or water. Afterward, they drank quinine-free alcohol (alcohol-only) or alcohol with quinine (100 mu M), in a limited daily access (LDA) two-bottle choice paradigm (2 h/day, 5 days/week, starting 3 h into the dark cycle), and achieved nearly binge level blood alcohol concentrations. Interestingly, a single, initial 24-h experience with alcohol-only enhanced subsequent quinine-resistant drinking. In contrast, mice that drank alcohol- quinine in the 24-h session showed significantly reduced alcohol quinine intake and preference during the subsequent LDA sessions, relative to mice that drank alcohol-only in the initial 24-h session and alcohol-quinine in LDA sessions. Thus, mice could find the concentration of quinine we used aversive, but were able to disregard the quinine after a single alcohol-only drinking session. Finally, mice had low intake and preference for quinine in water, both before and after weeks of alcohol-drinking sessions, suggesting that quinine resistance was not a consequence of increased quinine preference after weeks of drinking of alcohol quinine. Together, we demonstrate that a single alcohol-only session was sufficient to enable subsequent aversion-resistant consumption in C57BL/6 mice, which did not reflect changes in quinine taste palatability. Given the rapid development of quinine-resistant alcohol drinking patterns, this model provides a simple, quick, and robust method for uncovering the mechanisms that promote aversion resistant consumption. (C) 2016 Elsevier Inc. All rights reserved.
机译：成瘾在很大程度上通过病理动机进行了奖励，上瘾物质和酒精使用障碍（AUDS）继续提取对社会非常高的身体和经济损失。强制性的酒精饮酒，尽管存在负面后果，但在持续后果仍在继续，在治疗AUDS期间被认为是一个特殊的障碍。酒精的耐脂性驱动器已经在啮齿动物中进行了建模，即使醇掺入苦味奎宁的醇掺入，或者与另一种厌恶后果相结合，动物也继续消耗。在这里，我们描述了一个双瓶选择范式，其中C57BL / 6小鼠首先具有24-H进入15％的酒精或水。之后，他们用奎宁（100 mu m）喝奎宁酒（仅酒精）或酒精，限制每日访问（LDA）双瓶选择范式（2小时/天，5天/周，开始3小时进入黑暗循环），并实现了几乎泪水水平血液醇浓度。有趣的是，单一的，最初的24小时体验，仅增强随后的随后的奎宁饮用。相比之下，在24-H会话中喝酒的小鼠显着降低了酒精奎宁摄入和偏好，而在随后的LDA会话期间，相对于仅在最初的24-H季节和LDA酒精 - 奎宁中喝酒的小鼠会话。因此，小鼠可以找到我们使用厌恶的奎宁的浓度，但能够在单一的饮酒会议后无视奎宁。最后，小鼠的摄入量低，纯净的奎宁在水中的奎宁，两种饮酒会出现前后，表明奎宁抗性不是在饮用酒精奎尼宁饮用后增加奎宁偏好的结果。我们一起证明，仅单一的醇类会话足以使C57BL / 6小鼠中随后的厌恶消费，这没有反映奎宁味道性的变化。鉴于富含奎宁酒的酒精饮用图案的快速发展，该模型提供了一种简单，快速，稳健的方法，可以揭示促进促进抗避险消耗的机制。 （c）2016年Elsevier Inc.保留所有权利。

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  • 来源
    《Alcohol》 |2016年第2016期|共8页
  • 作者

    Lei Kelly; Wegner Scott A.; Yu Ji-Hwan; Simms Jeffrey A.; Hopf F. Woodward;

  • 作者单位

    Univ Calif San Francisco Dept Neurol Alcohol &

    Addict Res Grp San Francisco CA 94158 USA;

    Univ Calif San Francisco Dept Neurol Alcohol &

    Addict Res Grp San Francisco CA 94158 USA;

    Univ Calif San Francisco Dept Neurol Alcohol &

    Addict Res Grp San Francisco CA 94158 USA;

    Univ Calif San Francisco Dept Neurol Alcohol &

    Addict Res Grp San Francisco CA 94158 USA;

    Univ Calif San Francisco Dept Neurol Alcohol &

    Addict Res Grp San Francisco CA 94158 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

    Alcohol; Compulsive; C57BL/6 mice; Addiction; Model;

    机译：酒精;强迫;C57BL / 6鼠;成瘾;模型;

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