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首页> 外文期刊>American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons >Association of Higher CD4(+)CD25(high)CD127(low), FoxP3(+), and IL-2(+) T Cell Frequencies Early After Lung Transplantation With Less Chronic Lung Allograft Dysfunction at Two Years
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Association of Higher CD4(+)CD25(high)CD127(low), FoxP3(+), and IL-2(+) T Cell Frequencies Early After Lung Transplantation With Less Chronic Lung Allograft Dysfunction at Two Years

机译：肺部移植早期肺癌早期肺癌早期的高CD4（+）CD25（高），FoxP3（+）和IL-2（+）T细胞频率

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摘要

Regulatory T cells (Treg) can regulate alloantigens and may counteract chronic lung allograft dysfunction (CLAD) in lung transplantation. We analyzed Treg in peripheral blood prospectively and correlated percentages of subpopulations with the incidence of CLAD at 2 years. Among lung-transplanted patients between January 2009 and July 2011, only patients with sufficient Treg measurements were included into the study. Tregs were measured immediately before lung transplantation, at 3 weeks and 3, 6, 12, and 24 months after transplantation and were defined as CD4(+)CD25(high) T cells and further analyzed for CTLA4, CD127, FoxP3, and IL-2 expressions. Between January 2009 and July 2011, 264 patients were transplanted at our institution. Among the 138 (52%) patients included into the study, 31 (22%) developed CLAD within 2 years after transplantation. As soon as 3 weeks after lung transplantation, a statistically significant positive association was detected between Treg frequencies and later absence of CLAD. At the multivariate analysis, increasing frequencies of CD4(+)CD25(high)CD127(low), CD4(+)CD25(high)FoxP3(+) and CD4(+)CD25(high)IL-2(+) T cells at 3 weeks after lung transplantation emerged as protective factors against development of CLAD at 2 years. In conclusion, higher frequencies of specific Treg subpopulations early after lung transplantation are protective against CLAD development.
机译：调节性T细胞（Treg）可以调节血糖蛋原，可以抵消肺移植中的慢性肺同种异体移植功能障碍（包层）。我们分析了外周血前瞻性的Treg，并在2年时与包层发病率相关的群体的相关百分比。在2009年1月至2011年1月至2011年7月期间的肺移植患者中，只有足够的Treg测量患者纳入该研究。在肺移植前立即测量Tregs，在移植后3周和3,6,12和24个月内测量，并被定义为CD4（+）CD25（高）T细胞，并进一步分析CTLA4，CD127，FOXP3和IL- 2个表达。 2009年1月至2011年7月，264名患者在我们的机构移植。在该研究中包含的138名（52％）患者中，31（22％）在移植后2年内发育包层。在肺移植后3周，在Treg频率和后来没有包层之间检测到统计学上显着的阳性关联。在多变量分析中，增加CD4（+）CD25（高）CD127（低），CD4（+）CD25（高）FoxP3（+）和CD4（+）CD25（高）IL-2（+）T细胞的频率在肺移植后3周被出现为2年来保护覆层的保护因素。总之，肺移植早期特异性Treg患者的频率较高，对包层发育进行了保护。

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