Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside

Curcio Michele; Bradke Frank

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Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside

机译：中枢神经系统中的轴突再生：面对内部的挑战

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After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications-control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury.

机译：在成人哺乳动物中枢神经系统（CNS）受伤后，损伤的轴突未能再生。这种未能在胚胎发育期间和在外周神经系统（PNS）损伤后生长的显着潜力对比。几种细胞内机制 - 包括细胞骨骼动力学，轴突运输和贩运，传导性方案的信号和转录，以及表观遗传修饰控制轴突再生。在本文中，我们描述了内在机制的操纵如何引发不同生物中的再生反应以及如何实施策略，以形成CNS损伤后未来再生治疗的基础。

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来源
《Annual review of cell and developmental biology》 |2018年第2018期|共27页
作者
Curcio Michele; Bradke Frank;
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作者单位

German Ctr Neurodegenerat Dis DZNE Lab Axon Growth &

Regenerat D-53127 Bonn Germany;

German Ctr Neurodegenerat Dis DZNE Lab Axon Growth &

Regenerat D-53127 Bonn Germany;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
axon injury; axon regeneration; conditioning lesion; growth cone; intrinsic mechanisms; cytoskeleton;

机译：轴突损伤;轴突再生;调节病变;生长锥;内在机制;细胞骨架;

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专利

1. Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside [J] . Curcio Michele, Bradke Frank Annual review of cell and developmental biology . 2018,第期

机译：中枢神经系统中的轴突再生：面对内部的挑战
2. Updates and challenges of axon regeneration in the mammalian central nervous system [J] . Qian Cheng, Zhou Feng-Quan Journal of molecular cell biology . 2020,第10期

机译：哺乳动物中枢神经系统轴突再生的更新与挑战
3. Updates and challenges of axon regeneration in the mammalian central nervous system [J] . Cheng Qian, Feng-Quan Zhou 分子细胞生物学报（英文版） . 2020,第010期

机译：哺乳动物中枢神经系统轴突再生的更新与挑战
4. Developing Super-Paramagnetic Nanoparticles for Central Nervous System Axon Regeneration [C] . Mauris N De Silva, Monica V Almeida, Jeffrey L Goldberg Nano Science and Technology Institute(NSTI) Nanotechnology Conference and Trade Show(NSTI Nanotech 2007) vol.2; 20070520-24; Santa Clara,CA(US) . 2007

机译：开发用于中枢神经系统轴突再生的超顺磁性纳米粒子。
5. Degradable Polymer Constructs Delivering AG1478 to Promote Axon Regeneration in the Mature Mammalian Central Nervous System. [D] . Robinson, Rebecca. 2010

机译：可降解的聚合物构建体，提供AG1478以促进成熟的哺乳动物中枢神经系统中的轴突再生。
6. Updates and challenges of axon regeneration in the mammalian central nervous system [O] . Cheng Qian, Feng-Quan Zhou 2020

机译：哺乳动物中枢神经系统轴突再生的更新与挑战
7. Updates and challenges of axon regeneration in the mammalian central nervous system [O] . Cheng Qian, Feng-Quan Zhou 2020

机译：哺乳动物中枢神经系统轴突再生的更新与挑战
8. Activation of mTor Signaling by Gene Transduction to Induce Axon Regeneration in the Central Nervous System Following Neural Injury. [R] . Burke, R. E. 2017

机译：基因转导激活mTor信号诱导神经损伤后中枢神经系统轴突再生。

Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside

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